Human Cell Culture

Cancer Cell Lines Part 2

  • John R. W. Masters
  • Bernhard Palsson

Part of the Human Cell Culture book series (HUCC, volume 2)

Table of contents

  1. Front Matter
    Pages i-x
  2. Anne P. Wilson, Chris M. Garner
    Pages 1-53
  3. Swee Y. Sharp, Lloyd R. Kelland
    Pages 55-70
  4. P. G. Satyaswaroop
    Pages 71-78
  5. Robert L. Sutherland, Colin K. W. Watts, Christine S. L. Lee, Elizabeth A. Musgrove
    Pages 79-106
  6. Ignacio I. Wistuba, Arvind K. Virman, Adi E Gazdar
    Pages 107-119
  7. Masumi Sawada, Tsuneharu Miki
    Pages 121-125
  8. Martin F. Pera
    Pages 127-140
  9. Vadivel Ganapathy, Puttur D. Prasad, Frederick H. Leibach
    Pages 141-147
  10. H. K. Müller-Hermelink, Alexander Marx
    Pages 149-155
  11. Christopher Boshoff
    Pages 157-166
  12. Francis Ali-Osman
    Pages 167-184
  13. Christopher D. Lansford, Reidar Grenman, Henning Bier, Kenneth D. Somers, Sang Yoon Kim, Theresa L. Whiteside et al.
    Pages 185-255
  14. Toshimitsu Suzuki, Morimasa Sekiguchi
    Pages 257-291
  15. Michael G. Brattain, J. K. V. Willson, A. Koterba, S. Patil, S. Venkateswarlu
    Pages 293-303
  16. James M. Kozlowski, Julia A. Sensibar
    Pages 305-331
  17. Masayoshi Namba, Masahiro Miyazaki, Kenichi Fukaya
    Pages 333-343
  18. Noel A. Brownlee, Gian G. Re, Debra J. Hazen-Martin
    Pages 345-359
  19. Brenda L. Gallie, Judy Trogadis, Liping Han
    Pages 361-374
  20. Back Matter
    Pages 375-377

About this book


Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading.


biology brain tumors breast cancer cancer cancer research carcinoma cell cell lines gastric cancer immunology liver ovarian cancer tumor tumors

Editors and affiliations

  • John R. W. Masters
    • 1
  • Bernhard Palsson
    • 2
  1. 1.University College LondonLondonUK
  2. 2.Dept. of BioengineeringUniversity of California San DiegoUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-5878-7
  • Online ISBN 978-0-306-46861-2
  • Series Print ISSN 1389-2142
  • Buy this book on publisher's site