Growth Factors and their Receptors in Cancer Metastasis

  • C. R. Snyder
  • Wen G. Jiang
  • Kunio Matsumoto
  • Toshikazu Nakamura

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 2)

Table of contents

  1. Front Matter
    Pages i-x
  2. Theresa L. Whiteside, Torsten E. Reichert, Qing Ping Dou
    Pages 27-50
  3. Tracey A. Martin
    Pages 51-65
  4. Naoya Fujita, Takashi Tsuruo
    Pages 67-78
  5. Shin Ebara, Yasutomo Nasu, Takefumi Satoh, Satoru Shimura, Chris H. Bangma, Gerald W. Hull et al.
    Pages 79-91
  6. Zoran Culig, Marcus V. Cronauer, Alfred Hobisch, Georg Bartsch, Helmut Klocker
    Pages 93-106
  7. Emilia Mira, Rosa Ana Lacalle, Carlos Martínez-A, Santos Mañes
    Pages 107-166
  8. Sara Weiss Feigelson, Cheryl Fitzer-Attas, Lea Eisenbach
    Pages 167-186
  9. Yutaka Yonemura, Yoshio Endou, Takuma Sasaki, Kazuo Sugiyama, Tetumouri Yamashima, Taina Partaneri et al.
    Pages 223-239
  10. Gaynor Davies, Malcolm D. Mason, Wen G. Jiang
    Pages 277-290

About this book


about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).


angiogenesis breast cancer cancer cell gene therapy immunobiology leukemia metastasis molecular biology prostate cancer tumor

Editors and affiliations

  • C. R. Snyder
    • 1
  • Wen G. Jiang
    • 2
  • Kunio Matsumoto
    • 3
  • Toshikazu Nakamura
    • 3
  1. 1.University of KansasLawrence
  2. 2.University of Wales College of MedicineCardiffUK
  3. 3.University of Osaka Medical SchoolOsakaJapan

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-7141-0
  • Online ISBN 978-0-306-48399-8
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site