Sphingolipid Biology

  • Yoshio Hirabayashi
  • Yasuyuki Igarashi
  • Alfred H. MerrillJr.

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Yoshio Hirabayashi, Yasuyuki Igarashi, Alfred H. Merrill Jr.
      Pages 3-22
  3. Biosynthesis, Transport of Sphingolipids

    1. Front Matter
      Pages 23-23
    2. Jia Wei, Tokumbo Yerokun, Martina Liepelt, Amin Momin, Elaine Wang, Kentaro Hanada et al.
      Pages 25-47
    3. Irene Pankova-Kholmyansky, Anthony H. Futerman
      Pages 49-56
    4. Akemi Suzuki, Fumio Omae, Ayako Enomoto
      Pages 57-68
    5. Akio Kihara, Yasuyuki Igarashi
      Pages 95-106
    6. Kouichi Funato, Howard Riezman
      Pages 123-139
    7. Robert C. Dickson, Robert L. Lester
      Pages 141-150
  4. Generation and Degradation of Sphingolipid Signaling Molecules

    1. Front Matter
      Pages 151-151
    2. Kazuyuki Kitatani, L. Ashley Cowart, Yusuf A. Hannun
      Pages 153-165
    3. Youssef Zeidan, Norma Marchesini, Yusuf A. Hannun
      Pages 167-181
    4. Michael Maceyka, Sergio E. Alvarez, Sheldon Milstien, Sarah Spiegel
      Pages 197-206
    5. Susumu Mitsutake, Tack-Joong Kim, Yasuyuki Igarashi
      Pages 207-218
    6. Julie D. Saba
      Pages 219-230
  5. Membrane Domain and Biological Function

    1. Front Matter
      Pages 231-231
    2. Keiko Tamiya-Koizumi, Takashi Murate, Katsumi Tanaka, Yuji Nishizawa, Nobuhiro Morone, Jiro Usukura et al.
      Pages 233-244
    3. Miki Yokoyama, Tomoko Kimura, Sachio Tsuchida, Hiroaki Kaku, Kiyoshi Takatsu, Yoshio Hirabayashi et al.
      Pages 245-251
    4. Hiroyuki Kamiguchi
      Pages 253-261
    5. Gerrit van Meer, Maarten Egmond, David Halter
      Pages 263-270
  6. Membrane Lipid Domain and Human Pathobiology

    1. Front Matter
      Pages 271-271
    2. Jin-ichi Inokuchi, Kazuya Kabayama, Takashige Sato, Yasuyuki Igarashi
      Pages 273-284
    3. Yaacov Kacher, Anthony H. Futerman
      Pages 285-293
    4. Amit Choudhury, David L. Marks, Richard E. Pagano
      Pages 295-307
    5. Katsuhiko Yanagisawa
      Pages 309-317
    6. Irfan Y. Tamboli, Kai Prager, Esther Barth, Micheal Heneka, Konrad Sandhoff, Jochen Walter
      Pages 319-328
    7. Simon J. Myers, Garth A. Nicholson
      Pages 329-335
    8. Roser Gonzàlez-Duarte, Miquel Tuson, Gemma Marfany
      Pages 337-344
    9. Ronald T. Riley, Kenneth A. Voss, Marcy Speer, Victoria L. Stevens, Janee Gelineau-van Waes
      Pages 345-361
    10. Eva M. Schmelz, Holly Symolon
      Pages 363-381
  7. S1P Signaling and SIPR

    1. Front Matter
      Pages 383-383
    2. Maria Laura Allende, Richard L. Proia
      Pages 385-402
    3. Liliana Moreno, Steven M. Dudek, Joe G. N. Garcia
      Pages 403-414
    4. Yoh Takuwa, Naotoshi Sugimoto, Noriko Takuwa, Yasuyuki Igarashi
      Pages 415-425
    5. Yutaka Yatomi, Shinya Aoki, Yasuyuki Igarashi
      Pages 427-439
  8. Advanced Technology in Sphingolipid Biology

    1. Front Matter
      Pages 441-441
    2. Ichiro Miyoshi, Tadashi Okamura, Noriyuki Kasai, Tetsuyuki Kitmoto, Shinichi Ichikawa, Soh Osuka et al.
      Pages 443-451
    3. Ayako Koganeya-Kohyama, Yoshio Hirabayashi
      Pages 453-461
    4. Toshihide Kobayashi, Akiko Yamaji-Hasegawa
      Pages 475-482
    5. Hiroko Ikushiro, Akihiro Okamoto, Hideyuki Hayashi
      Pages 483-492
    6. Jin Young Hong, Jeremy C. Allegood, Samuel Kelly, Elaine Wang, Alfred H. Merrill Jr., May Dongmei Wang
      Pages 493-508
  9. Back Matter
    Pages 509-531

About this book


Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids as well as simpler sphingoid bases and derivatives are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book provides many examples of exciting new developments in sphingolipid biology/sphingolipidology that are changing our understanding of how multicellular organisms grow, develop, function, age, and die. Key areas addressed include sphingolipid biosynthesis, transport and membrane organization/lipid rafts; genetic approaches to understanding the roles of membrane sphingolipid biosynthesis; sphingolipid metabolism, specific G protein-coupled receptors (GPCRs), and signal transduction; and sphingolipid-associated disease and drug development.


Activation Lipid base biology biosynthesis cell cell membrane enzymes membrane metabolism migration protein proteins saccharomyces cerevisiae synthesis

Editors and affiliations

  • Yoshio Hirabayashi
    • 1
  • Yasuyuki Igarashi
    • 2
  • Alfred H. MerrillJr.
    • 3
  1. 1.Brain Science InstituteThe Institute of Physical and Chemical Research (Riken)SaitamaJapan
  2. 2.Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life ScienceHokkaido UniversitySapporoJapan
  3. 3.School of Biology and the Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaUSA

Bibliographic information