Recent Advances in Retinal Degeneration

  • Robert E. Anderson
  • Matthew M. LaVail
  • Joe G. Hollyfield

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 613)

Table of contents

  1. Front Matter
    Pages I-XXXIV
  2. Keynote Lectures

    1. Front Matter
      Pages 1-1
  3. Neuroprotection

    1. Front Matter
      Pages 37-37
    2. Junping Chen, Swanand Patil, Sudipta Seal, James F. McGinnis
      Pages 53-59
    3. Yogita Kanan, Anne Kasus Jacobi, Kjell Sawyer, David S. Mannel, Joyce Tombran Tink, Muayyad R. Al-Ubaidi
      Pages 61-67
    4. Yun-Zheng Le, Lixin Zheng, Yuwei Le, Edmund B. Rucker III, Robert E. Anderson
      Pages 69-74
    5. Markus Thiersch, Wolfgang Raffelsberger, Enrico Frigg, Marijana Samardzija, Patricia Blank, Olivier Poch et al.
      Pages 75-85
  4. Gene Therapy and Neuroprotection

    1. Front Matter
      Pages 87-87
    2. Alexis-Pierre Bemelmans, Corinne Kostic, Maité Cachafeiro, Sylvain V. Crippa, Dana Wanner, Meriem Tekaya et al.
      Pages 89-95
    3. Dibyendu Chakraborty, Patrick Whalen, Alfred S. Lewin, Muna I. Naash
      Pages 97-106
    4. Marina S. Gorbatyuk, William W. Hauswirth, Alfred S. Lewin
      Pages 107-112
    5. John J. Alexander, William W. Hauswirth
      Pages 121-128
    6. Kristina Narfstrô m, Mathias Seeliger, Chooi-May Lai, Vaegan, Martin Katz, Elizabeth P. Rakoczy et al.
      Pages 139-146
  5. Animal Models of Retinal Degeneration

    1. Front Matter
      Pages 155-155
    2. Drew Everhart, Ana Stachowiak, Yumiko Umino, Robert Barlow
      Pages 157-164
    3. Goldis Malek, Jeffery A. Jamison, Brian Mace, Patrick Sullivan, Catherine Bowes Rickman
      Pages 165-170
    4. Edda Fahl, Max Gassmann, Christian Grimm, Mathias W. Seeliger
      Pages 171-177
    5. Gerardo L. Paez, Barbara Zangerl, Kimberly Sellers, Gregory M. Acland, Gustavo D. Aguirre
      Pages 179-184
    6. Brian J. Raisler, Miho Nozaki, Judit Baffi, William W. Hauswirth, Jayakrishna Ambati
      Pages 185-192
  6. Molecular Genetics and Candidate Genes

    1. Front Matter
      Pages 201-201
    2. Stephen P. Daiger, Lori S. Sullivan, Anisa I. Gire, David G. Birch, John R. Heckenlively, Sara J. Bowne
      Pages 203-209
    3. Albert O. Edwards
      Pages 211-219
    4. Alessandro Iannaccone, Mohammad I. Othman, April D. Cantrell, Barbara J.Jennings, Kari Branham, Anand Swaroop
      Pages 221-227
    5. Linda Köhn, Konstantin Kadzhaev, Marie S.I. Burstedt, Susann Haraldsson, Ola Sandgren, Irina Golovleva
      Pages 229-234
    6. Mehrnoosh Saghizadeh, Novrouz B. Akhmedov, Debora B. Farber
      Pages 235-244
    7. Ruifang Sui, Fengrong Li, Jialiang Zhao, Ruxin Jiang
      Pages 245-252
    8. D. Joshua Cameron, Zhenglin Yang, Zhongzhong Tong, Yu Zhao, Alissa Praggastis, Eric Brinton et al.
      Pages 253-258
  7. Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration

    1. Front Matter
      Pages 259-259
    2. Kutralanathan Renganathan, Quteba Ebrahem, Amit Vasanji, Xiaorong Gu, Liang Lu, Jonathan Sears et al.
      Pages 261-267
    3. Vidyullatha Vasireddy, Majchrzak Sharon, Norman Salem Jr, Radha Ayyagari
      Pages 283-290
    4. Camasamudram Vijayasarathy, Yuichiro Takada, Yong Zeng, Ronald A. Bush, Paul A. Sieving
      Pages 291-297
  8. Basic Science Underlying Retinal Degeneration

    1. Front Matter
      Pages 299-299
    2. Muayyad R. Al-Ubaidi, Hiroyuki Matsumoto, Sadamu Kurono, Anil Singh
      Pages 301-311
    3. Michael E. Boulton, Jun Cai, Maria B. Grant, Yadan Zhang
      Pages 313-319
    4. Tanja Diemer, Daniel Gibbs, David S. Williams
      Pages 321-326
    5. J. Browning Fitzgerald, Anna P. Malykhina, Muayyad R. Al-Ubaidi, Xi-Qin Ding
      Pages 327-334
    6. Sukanya Karan, Jeanne M. Frederick, Wolfgang Baehr
      Pages 351-359
    7. Ann C. Morris, Tamera Scholz, James M. Fadool
      Pages 361-368

About this book


Retinal Degenerations is the result of The International Symposium on Retinal Degeneration which has become perhaps the most important research meeting in the field. The topics in this volume explore the etiology, cellular mechanisms, epidemiology, generics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.

Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early of congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.


development diseases endothelium etiology gene expression genetics hearing inflammation macular degeneration membrane mouse neuroprotection research retina stem cells

Editors and affiliations

  • Robert E. Anderson
    • 1
  • Matthew M. LaVail
    • 2
  • Joe G. Hollyfield
    • 3
  1. 1.University of Oklahoma Health Science CtrOklahoma CityUSA
  2. 2.USCF School of MedicineSan FranciscoUSA
  3. 3.Cole Eye Institute The Cleveland Clinic FoundationClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer New York 2008
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-0-387-74902-0
  • Online ISBN 978-0-387-74904-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site