Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells

  • Bernhelm Booß-Bavnbek
  • Beate Klösgen
  • Jesper Larsen
  • Flemming Pociot
  • Erik Renström

Part of the Systems Biology book series (SYSTBIOL, volume 2)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Systems Biology Approach to β-Cells

  3. Imaging and Sensors

    1. Front Matter
      Pages 119-119
    2. Patrick F. Antkowiak, Raghavendra G. Mirmira, Frederick H. Epstein
      Pages 121-146
    3. Joseph Bear, Gaëlle Charron, María Teresa Fernández-Argüelles, Salam Massadeh, Paul McNaughter, Thomas Nann
      Pages 185-220
    4. Beate Klösgen, Christine Rümenapp, Bernhard Gleich
      Pages 241-271
  4. Genetics and Proteomics

  5. Physiological, Pharmaceutical and Clinical Applications and Perspectives

    1. Front Matter
      Pages 387-387
    2. Torbjörn Lundgren, Olle Korsgren
      Pages 389-405
    3. Gary R. Hutchison, Eva M. Malone
      Pages 419-434
  6. Mathematical Modelling and Numerical Simulation

    1. Front Matter
      Pages 435-435
    2. Hans V. Westerhoff, Malkhey Verma, Frank J. Bruggeman, Alexey Kolodkin, Maciej Swat, Neil Hayes et al.
      Pages 437-458
    3. Leonid E. Fridlyand, Louis H. Philipson
      Pages 475-488
    4. Gianna Maria Toffolo, Morten Gram Pedersen, Claudio Cobelli
      Pages 489-503
    5. Darya Apushkinskaya, Evgeny Apushkinsky, Bernhelm Booß-Bavnbek, Martin Koch
      Pages 505-538
  7. Back Matter
    Pages 539-558

About this book


The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.

Editors and affiliations

  • Bernhelm Booß-Bavnbek
    • 1
  • Beate Klösgen
    • 2
  • Jesper Larsen
    • 3
  • Flemming Pociot
    • 4
  • Erik Renström
    • 5
  1. 1.Dept. IMFUFARoskilde UniversityRoskildeDenmark
  2. 2.University of Southern DenmarkOdense MDenmark
  3. 3.Department of Science, Systems and ModelUniversity of RoskildeRoskildeDenmark
  4. 4.Glostrup HospitalGlostrup Research InstituteGlostrupDenmark
  5. 5.Skåne University Hospital Malmö entr 72Lund University Diabetes CenterMalmöSweden

Bibliographic information