Immunologic Signatures of Rejection

  • Francesco M. Marincola
  • Ena Wang

Table of contents

  1. Front Matter
    Pages i-vii
  2. Preamble

    1. Front Matter
      Pages 1-1
  3. The Immune Biology of Rejection: Basic Principles

    1. Front Matter
      Pages 9-9
    2. Alberto Mantovani, Cecilia Garlanda, Paola Allavena, Antonio Sica, Massimo Locati
      Pages 11-16
    3. Douglas M. Noonan, Agostina Ventura, Antonino Bruno, Arianna Pagani, Adriana Albini
      Pages 57-75
    4. Alan M. Krensky, Carol Clayberger
      Pages 77-92
    5. Luciano Castiello, Marianna Sabatino, Ping Jin, Francesco M. Marincola, David Stroncek
      Pages 93-102
  4. Circulating Patterns Associated with Chronic and Acute Immune Pathology

    1. Front Matter
      Pages 103-103
    2. Damien Chaussabel, Nicole Baldwin, Derek Blankenship, Charles Quinn, Esperanza Anguiano, Octavio Ramilo et al.
      Pages 105-125
    3. F. M. Buonaguro, M. L. Tornesello, L. Buonaguro
      Pages 141-167
    4. Rebecca J. Critchley-Thorne, Hongxiang Yu, Peter P. Lee
      Pages 169-186
  5. Tissue-Specific Patterns Associated with Chronic Inflammatory Processes

  6. Signatures Associated with Acute Rejection

    1. Front Matter
      Pages 257-257
    2. Ena Wang, Francesco M. Marincola
      Pages 281-304
  7. Back Matter
    Pages 347-353

About this book


This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as “immune-mediated, tissue-specific destruction” (TSD), comprises a broad range of phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host versus graft reactions. Like different hands can turn on or off a switch, distinct mechanisms can trigger TSD; however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation leading to the activation of a restricted number of genes that we comprise in the immunologic constant of rejection (ICR) model. Although the ICR model does not address “why” rejection occurs but rather “how”, and it may not contribute an explanation for the determinism of rejection, it provides, if correct, a simplified road map about the convergent pathways leading to TSD. This offers the opportunity to identify a common target for immune manipulation with therapeutic purposes since ICR-related pathways are restricted in expression to the tissues in which TSD occurs while are shut off in the rest of a normal organism. The book includes chapters from outstanding basic and/or observational scientists that have contributed to this area either by defining mechanisms relevant to the understanding of the inflammatory switch or by describing how this occurs in human tissues under different pathological conditions. We would like to entice our reader(s) to test with us, through, the readings, whether our hypothesis is correct; we predict that common themes will emerge particularly if attention will be paid to the general phenomenon of TSD rather than the peculiarities of individual pathologies. With the hope of having contributed with this book something novel and important and we wish our reader a pleasant journey in the wondrous land of immune-mediated, tissue-specific destruction.


Cancer Research Ena Wang Immunologic Marincola Rejection Signatures

Editors and affiliations

  • Francesco M. Marincola
    • 1
  • Ena Wang
    • 2
  1. 1.Clinical Center, Dept. Transfusion MedicineNational Institute of Health (NIH)BethesdaUSA
  2. 2.BethesdaUSA

Bibliographic information