Epigenetic Alterations in Oncogenesis

  • Adam R. Karpf

Part of the Advances in Experimental Medicine and Biology book series (volume 754)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Epigenetic Marks and Mechanisms

    1. Front Matter
      Pages 1-1
    2. Bilian Jin, Keith D. Robertson
      Pages 3-29
    3. Melanie Ehrlich, Michelle Lacey
      Pages 31-56
    4. Moray J. Campbell, Bryan M. Turner
      Pages 81-107
    5. C. V. Andreu-Vieyra, G. Liang
      Pages 109-134
  3. The Impact of Epigenetic Alterations on Cancer Biology

    1. Front Matter
      Pages 135-135
    2. Muller Fabbri, Federica Calore, Alessio Paone, Roberta Galli, George A. Calin
      Pages 137-148
    3. Bernard W. Futscher
      Pages 179-194
    4. Yu-Wei Leu, Tim H.-M. Huang, Shu-Huei Hsiao
      Pages 195-211
  4. Clinical Implications and Analysis Methods

    1. Front Matter
      Pages 213-213
    2. Igor P. Pogribny, Ivan Rusyn
      Pages 215-232
    3. Carmen Marsit, Brock Christensen
      Pages 233-252
    4. Elizabeth A. Griffiths, Steven D. Gore
      Pages 253-283
    5. Curt Balch, Kenneth P. Nephew
      Pages 285-311
    6. Raman P. Nagarajan, Shaun D. Fouse, Robert J. A. Bell, Joseph F. Costello
      Pages 313-338
  5. Back Matter
    Pages 339-348

About this book


The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

Editors and affiliations

  • Adam R. Karpf
    • 1
  1. 1.University of Nebraska Medical CenterEppley Institute for Research in CancerOmahaUSA

Bibliographic information