The 4-Quinolones: Anti Bacterial Agents in Vitro

  • Geoff C. Crumplin

Part of the Springer Series in Applied Biology book series (SSAPPL.BIOLOGY)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Quinolones as Broad-spectrum Agents

  3. Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency

  4. The Influence of Oxygen upon Bactericidal Potency

    1. I. Morrissey, C. S. Lewin, J. T. Smith
      Pages 23-36
  5. Interactions of 4-Quinolones with Other Agents — The Importance in Assessing Practical Antibacterial Potency

  6. Molecular Effects of 4-Quinolones upon DNA Gyrase: DNA Systems

  7. Mechanisms of Killing of Bacteria by 4-Quinolones

    1. J. S. Wolfson, D. C. Hooper
      Pages 69-85
  8. Use of an In Vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase

    1. L. P. Elwell, L. M. Walton, J. M. Besterman, A. Hudson
      Pages 87-102
  9. Comparisons of DNA Gyrases from Different Species

    1. N. J. Robillard, B. L. Masecar, B. Brescia, R. Celesk
      Pages 103-114
  10. Structure-Activity Relationships of Fluoro-4-Quinolones

    1. L. A. Mitscher, P. V. Devasthale, R. M. Zavod
      Pages 115-146
  11. Aspects of Quinolone-DNA Interactions

    1. L. L. Shen, J. Baranowski, M. Nuss, J. Tadanier, C. Lee, D. T. W. Chu et al.
      Pages 147-158
  12. Selective Toxicity: The Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases

    1. T. D. Gootz, J. F. Barrett, H. E. Holden, V. A. Ray, P. R. McGuirk
      Pages 159-172
  13. In Vitro Genotoxicity Assessment and the Effects of 4-Quinolones upon Human Cells

  14. Mechanisms of Resistance to 4-Quinolones

    1. D. C. Hooper, J. S. Wolfson
      Pages 201-214
  15. In Vitro and In Vivo Mutation Frequencies to Resistance — do they Correlate in the Long Term?

  16. Measurement of the Frequency of Mutation to Resistance: The Importance of Testing under Physiological Conditions

  17. Plasmid-Borne Resistance to 4-Quinolones a Real or Apparent Absence?

    1. P. Courvalin, C. Poyart-Salmeron, E. Derlot
      Pages 241-248
  18. Poster Presentations

  19. Back Matter
    Pages 275-276

About this book


The 4-quinolone antibacterial agents have been under development and in use for over 25 years, but despite an enormous body of research work there are still many basic questions that remain unanswered. For example, we do not know how these agents kill susceptible cells - or even how the drugs interact with the target mol- ecule(s). However, we do know that the 4-quinolones display many properties which are not shared with any other group of antibacterial agents. This book raises the unanswered questions and assesses the potential significance to future chemotherapy of their unique features. The book also raises matters which are significant for physicians as well as for the pharmaceutical industry and the assessment of these agents by legislative bodies concerned with drug safety.


bacteria chemotherapy development drug drug safety research

Editors and affiliations

  • Geoff C. Crumplin
    • 1
  1. 1.Department of BiologyUniversity of YorkYorkUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag London 1990
  • Publisher Name Springer, London
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4471-3451-0
  • Online ISBN 978-1-4471-3449-7
  • Series Print ISSN 1431-8539
  • Buy this book on publisher's site