Alzheimer’s Dementia

Dilemmas in Clinical Research

  • Vijaya L. Melnick
  • Nancy Neveloff Dubler

Table of contents

  1. Front Matter
    Pages i-xx
  2. Legal and Science Background

    1. Front Matter
      Pages N1-N1
    2. Barry Reisberg, Betty Gordon, Martin McCarthy, Steven H. Ferris
      Pages 19-39
    3. Robert J. Levine
      Pages 41-50
  3. Personal Perspectives

  4. Historical, Legal, and Ethical Background

  5. Institutional Issues

  6. Competency to Give Consent

    1. Front Matter
      Pages N9-N9
    2. Barbara Stanley
      Pages 191-203
    3. Alan Meisel
      Pages 205-225
  7. Proxy and Derived Consent

    1. Front Matter
      Pages N11-N11
    2. Bruce L. Miller
      Pages 239-263
    3. Lance Tibbles
      Pages 265-294
    4. Vijaya L. Melnick, Nancy Dubler, Alan Weisbard, Robert N. Butler
      Pages 295-308
  8. Back Matter
    Pages 309-312

About this book


The National Institute on Aging (NIA) has historically been concerned with the protection of human subjects. In July 1977, the NIA sponsored a meeting to update and supplement guide­ lines for protecting those participating in Federal research pro­ jects. Although the basic guidelines had been in effect since 1966, it had been neglected to include the elderly as a vulnerable population. In November 1981, the NIA organized a conference on the ethical and legal issues related to informed consent in senile dementia cases. The present volume offers the latest and best thinking on Alzheimer's Dementia to have emerged from the dialog that was first embarked upon at the NIA meeting. Indeed, the issues and concerns it treats now seem even more relevant than they appeared historically because of the vastly greater awareness in the community of the entire spectrum of problems Alzheimer's disease confronts us all with. Our interest and concern is both humanitarian and self­ serving. Clearly older people must be protected from in­ appropriate research and careful attention must be paid to the circumstances under which research is conducted on those older persons who have given anything less than full consent. It is equally necessary, however, for the research enterprise to be protected so that today's elderly and those of the future can benefit from the fruits of research.


Alzheimer Ethical Issues Ethical Perspective aging alzheimer's disease assessment autonomy dementia ethics morality perception respect for autonomy

Editors and affiliations

  • Vijaya L. Melnick
    • 1
  • Nancy Neveloff Dubler
    • 2
  1. 1.Department of Biology and the Center of Applied Research and Urban PolicyUniversity of the District of ColumbiaUSA
  2. 2.Department of Social MedicineMontefiore Medical CenterBronxUSA

Bibliographic information