Ir Genes

Past, Present, and Future

  • Carl W. Pierce
  • Susan E. Cullen
  • Judith A. Kapp
  • Benjamin D. Schwartz
  • Donald C. Shreffler

Part of the Experimental Biology and Medicine book series (EBAM, volume 4)

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Genetic Organization of I-Region Genes

    1. Front Matter
      Pages 1-1
    2. Chella S. David, William P. Lafuse
      Pages 3-12
    3. Colleen E. Hayes, Robert M. Whitcomb, David P. Krum, Karen K. Klyczek, Debra A. Hullett
      Pages 13-17
    4. Mauro S. Sandrin, Jenni S. Craig, Ian F. C. McKenzie
      Pages 19-22
    5. William Walsh, Frances Pappas, Regina Skelly, Ted Hansen
      Pages 23-28
    6. Karen Klyczek, Debra Hullett, Colleen Hayes
      Pages 39-43
    7. William Lafuse, Michel Pierres, Chella S. David
      Pages 45-49
    8. V. Hauptfeld, M. Hauptfeld, M. Nahm, J. Trial, J. Kapp, D. Shreffler
      Pages 51-55
    9. J. K. Lunney, B. A. Osborne, C. Devaux, M. Pierres, D. H. Sachs
      Pages 57-61
    10. Sujay K. Singh, William P. Lafuse, David J. McKean, Chella S. David
      Pages 63-67
    11. Michelle Letarte, Jun Okamura, Jane B. L. Addis, Roland Tisch, Erwin W. Gelfand
      Pages 75-79
    12. Suzanne L. Epstein, David H. Sachs
      Pages 81-90
    13. L. B. Schook, D. H. Gutmann, L. E. Marlin, J. E. Niederhuber
      Pages 97-101
    14. J. S. Reichner, M. B. Zaleski
      Pages 103-107
  3. Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products

    1. Front Matter
      Pages 115-115
    2. Susan E. Cullen, David R. Lee, Carol Cowing, Ted H. Hansen, Elliot P. Cowan
      Pages 117-127
    3. J. H. Freed, S. J. Swiedler, J. M. Kupinski, M. L. Plunkett, G. W. Hart
      Pages 129-133
    4. P. P. Jones, C. E. Day, D. King, J. McNicholas, E. Sung
      Pages 135-146
    5. Benjamin D. Schwartz, Robert W. Karr, Carol Kannapell, Judy A. Stein, Yaffa Hahn, Elliot P. Cowan
      Pages 175-184
    6. Sanna M. Goyert, Jack Silver
      Pages 191-195
    7. Carolyn Katovich Hurley, Stephen Shaw, Lee Nadler, Stuart Schlossman, J. Donald Capra
      Pages 197-201
    8. Olivera J. Finn, Ellen Sung, Patricia Jones, Ronald Levy
      Pages 203-207
    9. J. A. Kobori, M. Steinmetz, J. McNicholas, M. Malissen, A. Winoto, C. Wake et al.
      Pages 209-215
    10. D. Mathis, C. Benoist, V. Williams, M. Kanter, H. McDevitt
      Pages 217-221
    11. R. N. Germain, R. Robinson, D. McKean, E. Choi, M. Mescher, J. Seidman
      Pages 223-231
    12. Henry Erlich, Deborah Stetler, Rosy Sheng-Dong, Jack Nunberg, Donald Pious, Carl Grumet et al.
      Pages 233-242
    13. Hriday K. Das, P. Andrew Biro, Cary Mullis, Simon K. Lawrance, Sherman M. Weissman
      Pages 243-247
  4. Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action

    1. Front Matter
      Pages 249-249
    2. George A. Dos Reis, Robert B. Clark, Ethan M. Shevach
      Pages 251-261
    3. David W. Thomas, Laurence B. Peterson, George D. Wilner
      Pages 277-281
    4. F. Manca, J. A. Clarke, E. E. Sercarz, A. Miller
      Pages 305-309

About this book


The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.


Antigen DNA Macrophages Monoclonal Antibodies T cell Vivo cell development gene genes genetics immune response immunity mutant regulation

Editors and affiliations

  • Carl W. Pierce
    • 1
  • Susan E. Cullen
    • 2
  • Judith A. Kapp
    • 1
  • Benjamin D. Schwartz
    • 3
  • Donald C. Shreffler
    • 4
  1. 1.Department of Pathology and Laboratory MedicineThe Jewish Hospital of St. LouisSt. LouisUSA
  2. 2.Department of Microbiology and ImmunologyWashington UniversitySt. LouisUSA
  3. 3.Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and ImmunologyWashington University School of MedicineSt. LouisUSA
  4. 4.Department of GeneticsWashington University School of MedicineSt. LouisUSA

Bibliographic information