Inflammatory Diseases and Copper

The Metabolic and Therapeutic Roles of Copper and Other Essential Metalloelements in Humans

  • John R. J. Sorenson

Part of the Experimental Biology and Medicine book series (EBAM, volume 2)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Physiological Aspects of Copper Metabolism

  3. Physiological Aspects of Copper Metabolism

  4. Biochemical Aspects of Copper Metabolism

    1. A. Zgirski, M. V. Chidambaram, E. Frieden
      Pages 171-181
    2. Edward D. Harris, Robert A. DiSilvestro, James E. Balthrop
      Pages 183-198
    3. Garry R. Buettner
      Pages 199-207
    4. M. P. Esnouf, A. I. Gainey, H. A. O. Hill, P. J. Thornalley
      Pages 209-220
  5. Biological Aspects of Copper Metabolism in Inflammation

  6. Antiinflammatory Activities of Copper Complexes

    1. Geoffrey B. West
      Pages 319-327
    2. Velo Giampaolo, Franco Luigina, Conforti Anita, Milanino Roberto
      Pages 329-345
    3. Helmar H. A. Dollwet, Steven P. Schmidt, Robert E. Seeman
      Pages 347-359
  7. Antiulcer, Antimicrobial, Anticancer Activities of Copper Complexes

    1. Vimal Kishore, T. M. Rolniak, K. Ramakrishna, John R. J. Sorenson
      Pages 363-373
    2. T. McP. Brown, J. S. Bailey, I. I. Iden, H. W. Clark
      Pages 391-407
    3. H. van der Goot, P. J. Pijper, H. Smit
      Pages 409-422
    4. Larry W. Oberley, Susan W. C. Leuthauser, Terry D. Oberley, John R. J. Sorenson, Robert F. Pasternack
      Pages 423-433
  8. Therapy of Rheumatic Diseases

  9. Possible Mechanisms of Action

    1. Ulrich Weser, Edmund Lengfelder, Karl-Heinz Sellinger, Lutz Schobotz
      Pages 513-527
    2. George J. Brewer, Ulana Bereza, Peter Kretzchmar, Lucia F. Brewer, Jon C. Aster
      Pages 529-542

About this book


In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu­ matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic dis­ eases. The first report that copper complexes had antiinflammatory activity in an animal model of inflammation appeared twenty-two years after the dis­ covery of essentiality. In 1976, it was suggested that the active forms of the antiarthritic drugs are their copper complexes formed in vivo. This sugges­ tion has been confirmed and extended in the interim in over 200 recent publications. Individual biomedical scientists from many countries who have published in these areas recently saw a need for a meeting to exchange current re­ supporting new hypotheses. We search results and discuss the evidence met on the University of Arkansas Medical Sciences campus in Little Rock, Arkansas, August 10-13, 1981. Participants came from Australia, England, France, Germany, Israel, Italy, The Netherlands, Norway, Poland, Scotland, Sweden, Switzerland, Wales, Zimbabwe, and over twenty of the United States.


Amino acid Arthritis Lipid Oxidation inflammation metabolism protein rheumatic diseases rheumatoid arthritis

Editors and affiliations

  • John R. J. Sorenson
    • 1
  1. 1.Department of Biopharmaceutical Sciences, College of Pharmacy and Department of Pharmacology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

Bibliographic information