Diuretics: Basic, Pharmacological, and Clinical Aspects

Proceedings of the International Meeting on Diuretics, Sorrento, Italy, May 26–30, 1986

  • V. E. Andreucci
  • Antonio Dal Canton

Part of the Developments in Nephrology book series (DINE, volume 18)

Table of contents

  1. Endogenous Natriuretic Factors

    1. P. Delva, M. Degan, C. Capra, M. De Gasperi, M. Menegazzi, A. Lechi
      Pages 177-179
    2. T. Tikkanen, I. Tikkanen, F. Fyhrquist, K. Metsärinne, K. J. Tötterman
      Pages 180-182
  2. Aquaretics

    1. Front Matter
      Pages 183-183
    2. L. B. Kinter
      Pages 185-187
    3. L. B. Kinter, W. Huffman, F. Stassen, S. Churchill
      Pages 196-202
    4. Berne Yee, Robert L. Cosby, Robert W. Schrier
      Pages 209-214
    5. L. B. Kinter, W. Mann, F. Brennan, W. Huffman, F. Stassen
      Pages 218-221
  3. Diuretics and Hypertension

    1. Front Matter
      Pages 223-223
    2. E. Ambrosioni, C. Borghi, S. Boschi, F. V. Costa, A. Mussi
      Pages 225-230
    3. J. L. Rodicio, J. M. Alcazar, J. Nieto, B. Miranda, L. M. Ruilope
      Pages 231-236
    4. M. P. Sambhi
      Pages 237-248
    5. C. Spieker, W. Zidek, W. Häcker, W. Schmidt, W. Tenschert, H. Vetter
      Pages 261-264
    6. D. Russo, E. Cofelice, G. Conte, A. Giunta, S. Maione, G. Romano et al.
      Pages 268-270
    7. G. Tramonti, C. Donadio, M. Bonadio, P. Lorusso, C. Bianchi
      Pages 271-273
    8. F. Andreasen, J. H. Christensen
      Pages 274-276
    9. N. Spannbrucker, I. Achhammer, W. Häcker
      Pages 277-279
    10. V. Canonico, G. Morgano, M. Petretta, R. Breglio, G. Conforti, C. Tedeschi et al.
      Pages 283-285
    11. L. I. Juncos, J. C. Cornejo, C. Ferrer
      Pages 286-288
    12. C. Romano, B. Copercini, P. Ghiringhelli, E. Gnocchi, F. Pecchini
      Pages 289-291
    13. P. Morachiello, U. Coli, S. Landini, A. Fracasso, F. Righetto, F. Scanferla et al.
      Pages 292-294
    14. P. Dessi’-Fulgheri, F. Bandiera, M. Oppes, P. Madeddu, F. Cocco, S. Rubattu et al.
      Pages 298-300
    15. F. Arzilli, S. Taddei, L. Graziadei, E. Bichisao, R. Giovannetti, A. Salvetti
      Pages 301-304
    16. L. A. Ferrara, T. Marotta, F. Pasanisi, P. Mastranzo, M. Mancini
      Pages 305-307
    17. R. Carretta, B. Fabris, S. Muiesan, M. Bardelli, F. Fischetti, R. Leprini et al.
      Pages 308-310
    18. F. Galletti, P. Strazzullo, G. Barba, R. Iacone, R. Gagliardi, M. Trevisan et al.
      Pages 311-313
    19. F. Quarello, R. Boero, C. Guarena, G. Giraudo, G. Beltrame, G. Piccoli
      Pages 314-316
    20. M. Carnovali, C. Borgnino, E. Crespi, M. Panozzo, A. Missaglia, G. Banderali et al.
      Pages 317-319
    21. L. S. Malatino, C. E. Fiore, A. Petralito, M. Lunetta, C. Fargetta, R. Foti et al.
      Pages 320-322
    22. V. Ortalda, E. Valvo, A. Fabris, N. Tessitore, L. Oldrizzi, C. Rugiu et al.
      Pages 323-325
    23. G. Licata, R. Scaglione, G. Parrinello, G. Capuana, N. Asta
      Pages 326-329
    24. P. Dorigo, R. M. Gaion, E. Valentini, I. Maragno
      Pages 330-332
  4. Diuretics and Cardiac Disease

  5. Diuretics and Renal Disease

    1. Front Matter
      Pages 365-365
    2. R. Faedda, A. Satta, G. F. Branca, F. Turrini, E. Bartoli
      Pages 367-372

About this book


The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car­ bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car­ bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.


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Editors and affiliations

  • V. E. Andreucci
    • 1
  • Antonio Dal Canton
    • 1
  1. 1.Department of NephrologyUniversity of NaplesNaplesItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1987
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9227-2
  • Online ISBN 978-1-4613-2067-8
  • Buy this book on publisher's site