Pathobiology of Cardiovascular Injury

From the proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR), Oklahoma City, Oklahoma September 13–15, 1984

  • H. Lowell Stone
  • William B. Weglicki

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 49)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Neural Components in Control of Cardiac Structure/Function

  3. Electrophysiology and Arrhythmias

    1. Front Matter
      Pages 61-61
    2. Dario DiFrancesco
      Pages 63-83
    3. M. R. Rosen, J. P. Moak, B. P. Damiano
      Pages 98-105
  4. Myocyte Models of Ischemia

    1. Front Matter
      Pages 107-107
    2. M. Lieberman, A. Lefurgey, E. Murphy, S. Liu
      Pages 145-155
    3. O. F. Schanne, M. Le Floch, R. Sauvé, M. D. Payet
      Pages 156-163
    4. K. H. McDonough, R. E. Shepherd, J. J. Spitzer
      Pages 164-174
  5. Ionic and Metabolic Response of the Heart to Ischemia

    1. Front Matter
      Pages 175-175
    2. K. I. Shine, J. Weiss, M. Bersohn
      Pages 180-189
    3. A. J. Liedtke, J. E. Orie, E. J. Toggart
      Pages 190-201
  6. Sarcolemma Structure and Function

    1. Front Matter
      Pages 203-203
    2. L. G. Herbette, D. G. Rhodes, D. W. Chester, R. A. Colvin, J. G. Sarmiento, Y. Vant Erve et al.
      Pages 245-257
    3. W. B. Weglicki, J. H. Kramer, R. C. Franson, D. C. Pang, K. Owens
      Pages 258-272
  7. Membrane Lipid Metabolism and Free Radicals in Myocardial Ischemia

    1. Front Matter
      Pages 273-273
    2. L. Grotyohann, J. R. Neely
      Pages 275-286
    3. K. R. Chien, L. M. Buja, J. T. Willerson
      Pages 317-321
    4. M. L. Hess, R. Franson, N. H. Manson
      Pages 322-333
    5. J. M. Downey, D. J. Hearse, D. M. Yellon, A. S. Manning
      Pages 334-349
  8. Vascular Endothelium — Platelet Interaction

    1. Front Matter
      Pages 351-351
    2. J. M. Gerrard, S. J. Israels, L. L. Friesen
      Pages 361-379
    3. R. C. Carroll, M. E. Wheeler
      Pages 380-396
  9. Differentiation and Aging in the Myocardium: Impact of Exercise on These Processes

About this book


This volume represents a part of the scientific proceedings of the Sixth Annual Meeting of the American Section of the International Society for Heart Research that was held in Oklahoma City from September 13-15, 1984. The chapters have been grouped according to the content of invited symposia on cardiovascular topics ranging from electrophysiology, autonomic control of the circulation, aging of the myocardium, mechanisms of cardiovascular injury, cultured heart cell studies, etc. Abstracts of all the papers presented at this meeting are included in Volume 16 (Supp. 1) of the Journal of Molecular and Cellular Cardiology. Since our understanding of the pathobiology of cardiovascular injury requires integrating knowledge from both basic and clinical sciences, the information presented in this volume extends from fundamental biochemical processes to pharmacological agents required to treat complex cardiac arrhythmias. At the molecular level, the structural lipids of the sarcolemma may be altered during myocardial ischemia; the role of free radicals in this process is one emerging area of active study. At the subcellular level, plasma membranes provide the anatomical basis for maintenance of optimal potentials of excitable cells; the anatomy and physiology of the sarcolemma ultimately determines the response to drugs and metabolic perturbants. At the cellular level, much progress has been made in our understanding of cultured and adult myocytes during ischemia and hypoxia; in particular, the electrophysiology of these model systems is well understood and several chapters address this approach.


anatomy cardiovascular cardiovascular function circulation electrophysiology heart

Editors and affiliations

  • H. Lowell Stone
    • 1
  • William B. Weglicki
    • 2
  1. 1.Health Sciences CenterUniversity of OklahomaUSA
  2. 2.Cardiovascular Research ProgramOklahoma Medical Research FoundationUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9639-3
  • Online ISBN 978-1-4613-2621-2
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site