A Potential Contraceptive for Men

  • Sheldon J. Segal

Part of the Reproductive Biology book series (RBIO)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction and History of Gossypol

    1. Sheldon J. Segal
      Pages 1-7
  3. Studies with Human Subjects and Non-Human Primates

    1. Guo-zhen Liu, Katherine C. Lyle, Jian Cao
      Pages 9-16
    2. Elsimar M. Coutinho, Sheldon J. Segal, Jose F. Melo, Ione Barbosa
      Pages 25-31
    3. Natwar R. Kalla, J. Foo, T. W. Kalpana, S. Hurkadli, A. R. Shetht
      Pages 33-43
  4. Toxicity and Teratogenicity Studies in Animals

    1. Wei-min Huang, Charles R. Katholi, W. T. Woods
      Pages 59-66
    2. Chin-Chuan Chang, Zhiping Gu, Yun-Yen Tsong
      Pages 67-77
    3. Gerhard F. Weinbauer, Natwar R. Kalla, Julian Frick
      Pages 79-88
    4. Allan R. Beaudoin
      Pages 89-109
  5. Mechanism of Action studies in vivo

  6. Mechanism of Action Studies in Vitro

    1. Erwin Rovan, Natwar R. Kalla, Julian Frick, H. Adam
      Pages 203-213
    2. Hideo Mohri, Sheldon J. Segal, Samuel S. Koide
      Pages 215-226
    3. Eimei Sato, Sheldon J. Segal, Samuel S. Koide
      Pages 227-235
    4. Chi-Yu Gregory Lee, Young S. Moon, Anthony Duleba, Albert F. Chen, James H. Yuan, Victor Gomel
      Pages 237-244
    5. Robert E. Corin, Howard C. Haspel, Andrew Peretz, Yun-Feng Ren, Kyoichi A. Watanabe, Martin Sonenberg
      Pages 257-265
  7. Back Matter
    Pages 267-271

About this book


The search for a reversible male contraceptive has centered upon the suppression of sperm production or sperm motility. Gossypol, a natural substance extracted from the cotton plant, appears to cause both of these effects. Its ability to reduce spermatogenesis in men is undeniable and has been demonstrated in both large studies in China and a smaller confirmatory study in Brazil. These investiga­ tions have revealed the remarkable fact that with gossypol, it is possible to separate an effect on the testis' gamete-producing function from an effect on its hormone-producing function. Thus, it is possible to maintain normal testosterone levels and libido while sperm counts (and motility) fall. Because of this unique and important action, gossypol warrants the fullest possible evaluation as a potential male contraceptive. Sheldon J. Segal vii ACKNOWLEDGMENT Lynn C. Landman played a major role in this publication by skillfully editing the manuscripts which were submitted for inclusion in this volume. Janet O'Connell added her efforts in editing, assembling texts and figures and handling final details required for publication. I thank these talented colleagues for their invaluable contributions.


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Editors and affiliations

  • Sheldon J. Segal
    • 1
  1. 1.The Rockeller FoundationNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1985
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9729-1
  • Online ISBN 978-1-4613-2809-4
  • Buy this book on publisher's site