Chemistry and Biology of Pteridines and Folates

Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17–22, 2001

  • Editors
  • Sheldon Milstien
  • Gregory Kapatos
  • Robert A. Levine
  • Barry Shane

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Gowland Hopkins Lecture

    1. Rowena G. Matthews
      Pages 1-8
  3. Novel Chemistry of Pteridines

    1. Wolfgang Pfleiderer
      Pages 9-17
    2. S. La Rosa, P. H. Boyle, C. L. Gibson, D. Guiney, C. J. Suckling
      Pages 25-29
    3. D. Guiney, P. H. Boyle, C. L. Gibson, S. La Rosa, C. J. Suckling
      Pages 31-35
    4. Sundar Vasudevan, Steven W. Bailey, Shirley B. Dillard, June E. Ayling
      Pages 37-41
    5. D. Guschin, W. Belliston, I. M. Müller, B. Fischer
      Pages 43-47
    6. Ning Chen, Kazuhisa Ikemoto, Takashi Sugimoto, Shizuaki Murata, Hiroshi Ichinose, Toshiharu Nagatsu
      Pages 49-53
  4. Pteridine-Dependent Enzymes: Structure, Function and Regulation

    1. Knut Teigen, Khanh K. Dao, Nils Åge Frøystein, Antonius C. F. Gorren, Bernd Mayer, Jeffrey McKinney et al.
      Pages 67-72
    2. Bostjan Kobe, Ian G. Jennings, Richard G. H. Cotton
      Pages 79-84
    3. Paul F. Fitzpatrick, S. Colette Daubner, Graham R. Moran
      Pages 91-95
    4. Jeffrey McKinney, Knut Teigen, Nils Åge Frøystein, Per M. Knappskog, Jan Haavik, Aurora Martínez
      Pages 97-102
    5. R. M. N. Carvalho, T. Solstad, N. E. Robinson, A. B. Robinson, T. Flatmark
      Pages 103-107
    6. Zhi-Qiang Wang, Chin-Chuan Wei, Jerome Santolini, Dennis J. Stuehr
      Pages 133-138
  5. Mechanism and Regulation of Pteridine Biosynthesis

    1. Christian Hesslinger, Valentino Parravicini, Christine Lapize, Irmgard Ziegler, Juan Rivera, Josef Pfeilschifter
      Pages 151-155
    2. Christian Hesslinger, Z. Chen, Amrita Ahluwalia, David L. Selwood, Patrick Vallance, Josef Pfeilschifter et al.
      Pages 157-161
    3. Mika Shimoji, Kei Hirayama, Gregory Kapatos
      Pages 163-167
    4. Nicholas Schramek, Andreas Bracher, Gerd Bader, Markus Fischer, Günter Auerbach, Markus Gütlich et al.
      Pages 169-173
    5. K. Fujimoto, T. Nonaka, M. Sakurai, S. Katoh
      Pages 175-179
    6. Keiko Sawabe, Kazumasa Yamamoto, Tadashi Kamata, Osuke K. Wakasugi, Hiroyuki Hasegawa
      Pages 199-204
    7. Hiroyuki Hasegawa, Kazumasa Yamamoto, Keiko Sawabe, Yoshie Matsuhashi, Kazuya Oguro, Osuke K. Wakasugi et al.
      Pages 205-210
  6. Pterins in Non-Mammalian Systems

    1. Janis M. O’Donnell, Dean G. Stathakis, Denise Burton, Zuomin Chen
      Pages 211-215
    2. Isabelle Pelletier, Peter Boyle, Thomas McDonald, Christian Hesslinger, Laure Bally-Cuif, Irmgard Ziegler
      Pages 217-222
    3. G Golderer, S Leitner, C Wild, P Gröbner, E R Werner, G Werner-Felmayer
      Pages 223-228
    4. Kazuhisa Ikemoto, Takashi Sugimoto, Shizuaki Murata, Masahiro Tazawa, Takahide Nomura, Hiroshi Ichinose et al.
      Pages 247-251
  7. Tetrahydrobiopterin and Endothelial Function

  8. Clinical Aspects of Pteridines

    1. Lina Elzaouk, Hatam Osmani, Walter Leimbacher, Anne Romstad, Jennifer Friedman, Mia Maccollin et al.
      Pages 277-284
    2. Chiho Sumi-Ichinose, Fumi Urano, Masayo Kojima, Risa Kuroda, Hiroaki Shiraishi, Yasumichi Hagino et al.
      Pages 285-289
    3. Ernst R. Werner, Gabriele Werner-Felmayer, Soheyl Bahrami, Wolfgang Strohmaier, Gerald Brandacher, Raimund Margreiter
      Pages 297-300

About this book


Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects.
Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information.


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Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5317-1
  • Online ISBN 978-1-4615-0945-5
  • Buy this book on publisher's site