Pulmonary Immunotoxicology

  • Mitchell D. Cohen
  • Judith T. Zelikoff
  • Richard B. Schlesinger

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Respiratory Tract

    1. Jack R. Harkema, Charles G. Plopper, Kent E. Pinkerton
      Pages 1-59
    2. Robert W. Lange, Meryl H. Karol
      Pages 61-84
    3. Richard B. Schlesinger
      Pages 85-105
  3. Adverse Effects of Altered Pulmonary Immunity

    1. M. Ian Gilmour
      Pages 107-126
    2. David J. P. Bassett, Deepak K. Bhalla
      Pages 127-151
    3. Thomas M. Jeitner, David Lawrence
      Pages 153-179
  4. Immunotoxicants

    1. Robert L. Sherwood
      Pages 181-197
    2. Kathleen E. Rodgers
      Pages 199-211
    3. Gregory L. Finch
      Pages 213-239
    4. Leigh Ann Burns-Naas
      Pages 241-265
    5. Lisa K. Ryan
      Pages 301-336
    6. Richard B. Schlesinger, Lung-Chi Chen, Judith T. Zelikoff
      Pages 337-352
    7. David B. Warheit
      Pages 353-367
    8. Donald E. Gardner
      Pages 387-409
  5. Risk Assessment

    1. Andrea K. Hubbard
      Pages 433-454
  6. Back Matter
    Pages 455-465

About this book


Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level.
Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.


assessment asthma autoimmunity chromium immunomodulation immunosuppression inflammation pesticide research selenium toxicity toxicology

Editors and affiliations

  • Mitchell D. Cohen
    • 1
  • Judith T. Zelikoff
    • 1
  • Richard B. Schlesinger
    • 1
  1. 1.Department of Environmental MedicineNew York University School of MedicineTuxedoUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7046-8
  • Online ISBN 978-1-4615-4535-4
  • Buy this book on publisher's site