Lithium Effects on Granulopoiesis and Immune Function

  • Arthur H. Rossof
  • William A. Robinson

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 127)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Introduction

    1. Ghanshyam N. Pandey, John M. Davis
      Pages 15-59
  3. Mechanisms of Lithium-Induced Granulocytosis

    1. G. Rothstein, A. K. Oshita, W. G. Harker, G. Lonngi, R. D. Christensen
      Pages 87-98
    2. Dharmvir S. Verma, Gary Spitzer, Axel R. Zander, Miloslav A. Beran, Karel A. Dicke
      Pages 111-126
  4. Animal Models

    1. Robert A. Joyce, Paul A. Chervenick
      Pages 145-154
    2. A. H. Rossof, K. M. Fehir, H. S. Budd, A. Murthy, S. G. Economou
      Pages 155-166
    3. William P. Hammond, David C. Dale
      Pages 167-173
  5. Lithium Attenuation of Anti-Cancer Chemotherapy

    1. Dominique J. Charron, Thierry Schmitt, Laurent Degos
      Pages 175-186
    2. Peter G. Steinherz, Gerald Rosen, Fereshteh Ghavimi, Norma Wollner, Ying Wang, Denis R. Miller
      Pages 231-243
    3. U. Visca, F. Mensi, M. P. Spina, R. Bombara, B. Giraldi, A. Massari et al.
      Pages 245-255
  6. Lithium Therapy of Neutropenic Disorders

    1. William A. Robinson, Maureen A. Entringer, James Huber, Ramesh Gupta
      Pages 281-291
    2. Helen S. L. Chan, Melvin H. Freedman, E. Fred Saunders
      Pages 293-304
    3. Richard S. Stein, Carol A. Howard
      Pages 321-332
  7. Neutrophil Function in the Presence of

    1. Myron S. Cohen, Behnam Zahkireh, Julia A. Metcalf, Richard K. Root
      Pages 335-346
    2. H. Daniel Perez, Howard B. Kaplan, Ira M. Goldstein, Louis Shenkman, William Borkowsky
      Pages 357-370
    3. J. N. Siegel, R. B. Johnston Jr., R. S. Lowe, P. S. Epstein, A. H. Rossof
      Pages 371-388
    4. William R. Friedenberg, James J. Marx
      Pages 389-399
  8. Immunologic Effects of Lithium

    1. William Borkowsky, Louis Shenkman, Scott Wadler, Robert S. Holzman, Baron Shopsin
      Pages 417-427
    2. E. W. Gelfand, R. Cheung, D. Hastings, H.-M. Dosch
      Pages 429-446
    3. Hans-Michael Dosch, David Matheson, Ruud K. B. Schuurman, Erwin W. Gelfand
      Pages 447-462
    4. F. Anthony Greco
      Pages 463-469
  9. Back Matter
    Pages 471-475

About this book


This monograph contains papers which resulted from an international workshop on the effects of lithium on the hematopoietic and immunologic systems. The meeting was held at the John L. and Beatrice Keeshin International Biomedical Systems Planning Center of Rush University in Eagle River, Wisconsin from June 6 through June 9, 1979. The object of this conference was to bring together scientists from around the world with an interest in the effects of lithium and its potential use in human disease to bolster and stimulate the hematologic and immune systems. These topics seemed to us to be important and the time seemed right for bringing together the workers in these fields to exchange ideas and recent research results. We sought to bring together basic research scientists trying to uncover the mechanism of action of lithium in the stimulation of granulo­ poiesis and in its immunologic effects, together with those involved in clinical care and the use of lithium as a therapeutic tool in neoplastic and non-neoplastic disorders. This was the first use of the Keeshin Center for such a program. The sessions were conducted in a relaxed atmosphere with a good deal of give-and-take by all the participants. The editors of this book hope that it will be useful as the first volume completely devoted to these applications of lithium in these new and, as yet, incompletely developed fields.


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Editors and affiliations

  • Arthur H. Rossof
    • 1
  • William A. Robinson
    • 2
  1. 1.Rush Medical CollegeChicagoUSA
  2. 2.University of Colorado Medical CenterDenverUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1980
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-0261-3
  • Online ISBN 978-1-4757-0259-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site