Tumor Suppressor Genes in Human Cancer

  • David E. Fisher

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Analysis and Clinical Implications of Tumor Suppressor Genes

    1. Front Matter
      Pages 1-1
    2. Jordan A. Kreidberg, Thomas A. Natoli
      Pages 3-28
    3. Taoufik Ouatas, Melanie T. Hartsough, Patricia S. Steeg
      Pages 49-77
    4. Jinyan Du, David E. Fisher
      Pages 79-101
    5. Alex Matter
      Pages 103-128
  3. Tumor Suppressor Pathways

    1. Front Matter
      Pages 129-129
    2. Lilia Stepanova, J. Wade Harper
      Pages 131-157
    3. Margaret Ashcroft, Karen H. Vousden
      Pages 159-181
    4. Alexander Kamb, Ken McCormack
      Pages 183-195
    5. Guo-Min Li, Scott McCulloch, Liya Gu
      Pages 197-229
    6. Jen Jen Yeh, William R. Sellers
      Pages 231-251
    7. André Bernards, Andrea I. McClatchey
      Pages 253-280
    8. Othon Iliopoulos, William G. Kaelin Jr.
      Pages 281-305
    9. Aswin L. Menke, Nick D. Hastie
      Pages 307-350
    10. Yanan Kuang, Irene Garcia-Higuera, Eric Nisbet-Brown, Anna Savoia, Alan D. D’Andrea
      Pages 351-373
  4. Back Matter
    Pages 375-386

About this book


While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Additional coverage is accorded animal models, viral oncoproteins as probes, and cancer metastasis. An extensive chapter on cancer drug discovery is provided to help integrate the new molecular oncology with technologies which fuel the pragmatic search for improved cancer therapeutics.
Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.


DNA Tumor anemia apoptosis cancer cell cell death drug drug discovery genetics metastasis molecular biology research

Editors and affiliations

  • David E. Fisher
    • 1
  1. 1.Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-61737-198-1
  • Online ISBN 978-1-59259-230-2
  • Buy this book on publisher's site