Life-Span Extension

Single-Cell Organisms to Man

  • Christian Sell
  • Antonello Lorenzini
  • Holly M. Brown-Borg

Part of the Aging Medicine book series (AGME)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Yeast

  3. Caenorhabditis elegans

  4. Drosophila melanogaster

    1. Front Matter
      Pages 58-58
    2. Robert Arking
      Pages 59-73
  5. Rodents

    1. Front Matter
      Pages 90-90
    2. Michelle E. Matzko, Roger J. McCarter, Edward J. Masoro
      Pages 91-114
    3. Holly M. Brown-Borg, Sunita Sharma, Kurt E. Borg, Sharlene G. Rakoczy
      Pages 115-130
  6. Comparative Biology of Aging

    1. Front Matter
      Pages 132-132
  7. Aging in Humans

    1. Front Matter
      Pages 174-174
    2. Miriam Capri, Stefano Salvioli, Elisa Cevenini, Laura Celani, Federica Sevini, Elena Bellavista et al.
      Pages 175-191
  8. Back Matter
    Pages 193-198

About this book


In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.


Caenorhabditis elegans Life span Life-span extension Longevity Mammals Markers Neuroendocrine pathways Single mutations Species Stress response Yeast aging insulin/insulin-like growth factor (IGF) pathways mTOR pathway

Editors and affiliations

  • Christian Sell
    • 1
  • Antonello Lorenzini
    • 2
  • Holly M. Brown-Borg
    • 3
  1. 1.College of MedicineDrexel UniversityPhiladelphiaU.S.A.
  2. 2.College of MedicineDrexel UniversityPhiladelphiaU.S.A.
  3. 3.School of Medicine & Health SciencesUniversity of North DakotaGrand ForksU.S.A.

Bibliographic information