Osteosarcopenia: Bone, Muscle and Fat Interactions

  • Gustavo Duque

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Biology of Muscle and Bone

    1. Front Matter
      Pages 1-1
    2. Joseph Elphingstone, Mark W. Hamrick
      Pages 3-27
    3. Julie A. Pasco
      Pages 45-71
    4. Chenglin Mo, Zhiying Wang, Leticia Brotto, Donnalee Pollack, Jian Huang, Marco Brotto
      Pages 73-97
    5. Lilian I. Plotkin, Hannah M. Davis
      Pages 99-121
    6. Ahmed Al Saedi, Craig A. Goodman, Damian E. Myers, Alan Hayes, Gustavo Duque
      Pages 123-143
    7. Xuzhu Lin, Alan Hayes, Glenn McConell, Gustavo Duque, Tara C. Brennan-Speranza, Itamar Levinger
      Pages 145-171
    8. Christian M. Girgis
      Pages 173-190
    9. Guillaume T. Duval, Hélène Meytadier, Cédric Annweiler, Gustavo Duque
      Pages 191-213
    10. Katerina Trajanoska, Fernando Rivadeneira
      Pages 215-230
  3. Clinical Characteristics

    1. Front Matter
      Pages 231-231
    2. Alberto Frisoli Jr
      Pages 233-242
    3. Adam J. Kuchnia, Neil Binkley
      Pages 243-263
    4. Barbara Obermayer-Pietsch, Markus Herrmann
      Pages 265-321
    5. David Scott
      Pages 323-343
    6. Jacopo Antonino Vitale, Francesco Negrini, Giuseppe Banfi
      Pages 345-361
  4. Back Matter
    Pages 381-383

About this book


This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. 

With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. 

Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat –  followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. 

This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. 

The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.


Osteosarcopenia Sarcopenia Biological mechanisms of bone and muscle loss Osteoporosis Muscle Bone Mesenchymal Stem Cells

Editors and affiliations

  1. 1.Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, VIC, Australia, Department of Medicine-Western HealthMelbourne Medical School, The University of MelbourneSt. AlbansAustralia

Bibliographic information