Translating Molecules into Medicines

Cross-Functional Integration at the Drug Discovery-Development Interface

  • Shobha N. Bhattachar
  • John S. Morrison
  • Daniel R. Mudra
  • David M. Bender

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 25)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Discovery, Development and Commercialization of Drug Candidates: Overview and Issues

    1. Front Matter
      Pages 1-1
    2. David C. Swinney
      Pages 3-25
  3. Druggable Targets, Discovery Technologies and Generation of Lead Molecules

    1. Front Matter
      Pages 39-39
    2. Matthew L. Danielson, Bingjie Hu, Jie Shen, Prashant V. Desai
      Pages 81-117
    3. Thomas K. Baker, Steven K. Engle, Bartley W. Halstead, Brianna M. Paisley, George H. Searfoss, Jeffrey A. Willy
      Pages 119-162
  4. Optimizing Lead Molecules into Drug Candidates

    1. Front Matter
      Pages 163-163
    2. Bianca M. Liederer, Xingrong Liu, Simon Wong, Daniel R. Mudra
      Pages 165-230
    3. Shobha N. Bhattachar, Jeffrey S. Tan, David M. Bender
      Pages 231-266
    4. Marcus H. Andrews, Vincent L. Reynolds
      Pages 267-294
  5. Early Clinical Development of Drug Candidates

    1. Front Matter
      Pages 295-295
    2. Margaret S. Landis
      Pages 297-315
    3. Catherine M. Ambler, Avinash G. Thombre, Madhushree Gokhale, John S. Morrison
      Pages 317-339
    4. Brinda Tammara, Sangeeta Raje, William McKeand, Joan M. Korth-Bradley
      Pages 341-372
  6. Evolution of the Drug Discovery/Development Paradigm

    1. Front Matter
      Pages 389-389
    2. Neil Mathias, Srini Sridharan
      Pages 391-419
    3. John S. Morrison, Michael J. Hageman
      Pages 421-447
  7. Back Matter
    Pages 449-461

About this book


Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.


competitive intelligence preformulation therapeutic precision medicine drug discovery drug development

Editors and affiliations

  • Shobha N. Bhattachar
    • 1
  • John S. Morrison
    • 2
  • Daniel R. Mudra
    • 3
  • David M. Bender
    • 4
  1. 1.Small Molecule Design and DevelopmentEli Lilly and CompanyIndianapolisUSA
  2. 2.Pharmaceutical Candidate OptimizationBristol-Myers SquibbWallingfordUSA
  3. 3.ADME, Drug DispositionEli Lilly and CompanyIndianapolisUSA
  4. 4.Small Molecule Design and DevelopmentEli Lilly and CompanyIndianapolisUSA

Bibliographic information