Inflammation-Associated Depression: Evidence, Mechanisms and Implications

  • Robert Dantzer
  • Lucile Capuron

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 31)

Table of contents

  1. Front Matter
    Pages i-x
  2. Celina S. Liu, Alexander Adibfar, Nathan Herrmann, Damien Gallagher, Krista L. Lanctôt
    Pages 3-30
  3. Barbara Strasser, Barbara Sperner-Unterweger, Dietmar Fuchs, Johanna M. Gostner
    Pages 95-115
  4. Christopher R. Pryce, Adriano Fontana
    Pages 139-154
  5. Caitlín N. M. Hastings, Hannah Sheridan, Carmine M. Pariante, Valeria Mondelli
    Pages 321-338

About this book


Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.


Biological Psychiatry Depression Inflammation Cytokine Indoleamine 2,3 dioxygenase Kynurenine Phenylalanine Tetrahydrobiopterin Obesity Cardiovascular disorders

Editors and affiliations

  • Robert Dantzer
    • 1
  • Lucile Capuron
    • 2
  1. 1.Department of Symptom ResearchThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Nutrition and Integrative NeurobiologyINRA, University of BordeauxBordeauxFrance

Bibliographic information