The Biology of Krüppel-like Factors

  • Ryozo Nagai
  • Scott L. Friedman
  • Masato Kasuga

Table of contents

  1. Front Matter
    Pages i-viii
  2. Overview

  3. Molecular Control of Krüppel-like Factor Function

    1. Toshio Nagashima, Fumiaki Hayashi, Takashi Umehara, Shigeyuki Yokoyama
      Pages 21-31
    2. Navtej S. Buttar, Gwen A. Lomberk, Gaurang S. Daftary, Raul A. Urrutia
      Pages 33-49
    3. Richard C. M. Pearson, Briony H. A. Jack, Stella H. Y. Lee, Alister P. W. Funnell, Merlin Crossley
      Pages 51-64
  4. Krüppel-like Factors in Development and Differentiation

    1. Yizeng Yang, Jonathan P. Katz
      Pages 67-82
    2. Kensuke Takada, Kristin A. Hogquist, Stephen C. Jameson
      Pages 95-106
    3. Marie-Pier Tétreault, Jonathan P. Katz
      Pages 107-119
    4. Masatsugu Ema, Satoru Takahashi, Yoshiaki Fujii-Kuriyama
      Pages 131-138
  5. Krüppel-like Factors in Organ Function and Disease

    1. Goutham Narla, Scott L. Friedman
      Pages 141-150
    2. Wataru Ogawa, Hiroshi Sakaue, Masato Kasuga
      Pages 151-157
    3. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain
      Pages 159-171
    4. Guillermo García-Cardeña, Guadalupe Villarreal
      Pages 173-184
    5. Vincent W. Yang
      Pages 205-219
  6. Diagnostic and Therapeutic Applications of Krüppel-like Factors

    1. Analisa DiFeo, Goutham Narla, John A. Martignetti
      Pages 223-244
    2. Ichiro Manabe, Ryozo Nagai
      Pages 245-252
  7. Back Matter
    Pages 253-258

About this book


Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise treatise written to date by leading experts in the field, it serves as an authoritative review of this family of molecules and is an essential reference for all who are interested in KLFs. The book also explores the potential of KLFs as targets for novel therapeutics and diagnostics, and will be invaluable in those fields.


biology cancer cell biology cells cellular differentiation development diagnostics genes liver lymphocytes molecular mechanisms pathogenesis regulation tissue transcription

Editors and affiliations

  • Ryozo Nagai
    • 1
  • Scott L. Friedman
    • 2
  • Masato Kasuga
    • 3
  1. 1.Department of Cardiovascular Medicine, Graduate School of MedicineThe University of TokyoBunkyo-kuJapan
  2. 2.Division of Liver DiseasesMount Sinai School of MedicineNew YorkUSA
  3. 3.Research Institute, International Medical Center of JapanShinjuku-kuJapan

Bibliographic information