The Comparative Biology of Aging

  • Norman S. Wolf

Table of contents

  1. Front Matter
    Pages i-ix
  2. Adam Spong, Andrzej Bartke
    Pages 43-68
  3. Rozalyn M. Anderson, Ricki J. Colman, Richard Weindruch
    Pages 69-96
  4. Daniel L. Smith Jr., Jeffrey S. Smith
    Pages 123-146
  5. Matt Kaeberlein, Lara S. Shamieh
    Pages 147-161
  6. Yun Shi, Rochelle Buffenstein, Holly Van Remmen
    Pages 163-190
  7. Jan Vijg, Ana Maria Garcia, Brent Calder, Martijn Dollé
    Pages 191-200
  8. N.M.V. Gomes, J.W. Shay, W. E. Wright
    Pages 227-258
  9. Dao-Fu Dai, Robert J. Wessells, Rolf Bodmer, Peter S. Rabinovitch
    Pages 259-286
  10. David J. Marcinek, Jonathan Wanagat, Jason J. Villarin
    Pages 287-317
  11. Catherine A. Wolkow, Sige Zou, Mark P. Mattson
    Pages 319-352
  12. Janko Nikolich-Žugich, Luka Čičin-Šain
    Pages 353-376
  13. Back Matter
    Pages 377-391

About this book


Cover copy: Wolf, Norman (ed.), The Comparative Biology of Aging

The processes of aging and death remain one of the most fascinating, and mysterious, areas of biological research. Huge anomalies between species raise questions the answers to which could have fundamental implications for the field of medical science. As scientists unlock the secrets of the exceptionally long-lived little brown bat (up to 34 years), or the common Budgerigar which despite having a metabolic rate 1.5 times that of a laboratory mouse, can live for up to 20 years, it has become more important than ever to be able to make a comparative analysis of the various species used in research.

Dealing with every one of the species that are employed in laboratory research, this is the first book on the subject of aging that provides detailed comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules. The comparative data, supplied in 15 chapters by leading experts, provides information on fields as disparate as telomere function and loss, the importance of the Sirtuins and Tor, the influence of hormones on lifespans, the relationship between body size and lifespan, the effects of restricted calorific intake, age-related changes in cell replication, and DNA damage and repair. Chapters are devoted to cardiac aging, comparative skeletal muscle aging, the aging of the nervous and immune systems, the comparative biology of lyosomal function and how it is affected by age, and many other key areas of research.

This much-needed text will provide scientists working in a wide spectrum of fields with key data to aid them in their studies.


DNA Gerontology Immune System Organelle Telomere Vivo influence

Editors and affiliations

  • Norman S. Wolf
    • 1
  1. 1.SeattleU.S.A.

Bibliographic information