Bacterial Chromatin

  • Remus T. Dame
  • Charles J. Dorman

Table of contents

  1. Front Matter
    Pages i-x
  2. Structure and Organization of the Bacterial Chromosome

    1. Front Matter
      Pages 1-1
    2. William Margolin
      Pages 13-30
    3. Peter L. Graumann
      Pages 31-48
    4. Conrad L. Woldringh
      Pages 71-96
    5. N. Patrick Higgins, B. M. Booker, Dipankar Manna
      Pages 117-148
    6. Ümit Pul, Rolf Wagner
      Pages 149-173
    7. Hanne Ingmer
      Pages 175-201
  3. Chromatin Organization in Archaea and Eukaryotes

    1. Front Matter
      Pages 204-204
    2. Stephen D. Bell, Malcolm F. White
      Pages 205-217
    3. Andrew Travers, Georgi Muskhelishvili
      Pages 219-241
  4. Regulation by Nucleoid-Associated Proteins

    1. Front Matter
      Pages 244-244
    2. Charles J. Dorman
      Pages 245-250
    3. William Wiley Navarre
      Pages 251-322
    4. Georgi Muskhelishvili, Andrew Travers
      Pages 323-351
    5. Stacey N. Peterson, Norbert O. Reich
      Pages 353-364
    6. Amalia Muñoz, Marc Valls, Víctor de Lorenzo
      Pages 365-393
    7. Dale E. A. Lewis, Sang Jun Lee, Sankar Adhya
      Pages 395-417
    8. Douglas F. Browning, David C. Grainger, Meng Xu, Stephen J. W. Busby
      Pages 419-443
    9. Springer Science+Business Media B.V.
      Pages 444-444
  5. Back Matter
    Pages 445-448

About this book


The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny nucleoid, have remained elusive. How is it that bacteria are able to package their genetic information within the confined space of the nucleoid while at the same time making it accessible for gene expression and DNA replication?

This book, featuring the latest research by leading experts, describes the advanced methods being applied to the problem and shows how their work is contributing to our growing understanding of the ways that bacterial DNA storage, replication, recombination and gene expression are managed and coordinated. With due consideration paid to archaea and eukaryotes, the authors show how evolution in bacteria has provided solutions to these problems that range from the very sophisticated to the surprisingly simple.

This comprehensive overview of bacterial chromatin clearly defines the fundamental concepts and goes on to show how cells inherit both chromosomal and extra-chromosomal genetic information at cell division. Several chapters are devoted to the central role played by nucleoid-associated proteins, with specific material on imaging the nucleoids, the physics of their structure and segregation, and the transcriptional regulation conducted by nucleoid-associated proteins. No other book currently available provides such a complete picture of these essential cellular processes.


Archaea DNA DNA replication DNA storage Eukaryota bacterial DNA storage dynamics recombination

Editors and affiliations

  • Remus T. Dame
    • 1
    • 2
  • Charles J. Dorman
    • 3
  1. 1.Leiden Institute of ChemistryLeiden UniversityLeidenNetherlands
  2. 2.Division of Physics and Astronomy Section Physics of Complex SystemsVU University AmsterdamAmsterdamThe Netherlands
  3. 3.Department of Microbiology School of Genetics and MicrobiologyUniversity of Dublin Trinity CollegeDublin 2Ireland

Bibliographic information