Biomedical Aspects of Histamine

Current Perspectives

  • Nancy Khardori
  • Rahat Ali Khan
  • Trivendra Tripathi

Table of contents

  1. Front Matter
    Pages i-xxxv
  2. Histamine Biology and Physiology

    1. Front Matter
      Pages 1-1
    2. Mohammed Shahid, Trivendra Tripathi, Nancy Khardori, Rahat Ali Khan
      Pages 3-13
    3. Satoshi Tanaka, Atsushi Ichikawa
      Pages 15-30
  3. Enzymology in Histamine Biology

    1. Front Matter
      Pages 31-31
    2. Almudena Pino-Ángeles, Aurelio A. Moya-García, Miguel Ángel Medina, Francisca Sánchez-Jiménez
      Pages 33-57
  4. Pharmacology of Histamine Noble Receptors and Their Ligands in Drug Development

    1. Front Matter
      Pages 59-59
    2. Mohammed Shahid, Trivendra Tripathi, Rahat Ali Khan, Nancy Khardori, Ali Ibrahim Al-Sultan, Hamdan Ibrahim AL-Mohammed et al.
      Pages 61-100
  5. Histamine Role in Immune Modulation and Regulation

    1. Front Matter
      Pages 101-101
    2. Trivendra Tripathi, Mohammed Shahid, Farrukh Sobia, Anuradha Singh, Haris M. Khan, Rahat Ali Khan et al.
      Pages 133-147
  6. Histamine in Regulation of Cell Proliferation and Differentiation

    1. Front Matter
      Pages 149-149
    2. Manzoor M. Khan
      Pages 151-174
    3. Jameel Ahmad, Monika Misra, Waseem Rizvi, Anil Kumar
      Pages 175-198
  7. Histamine Role in Pathogenesis and Diagnosis of Allergic, Inflammatory, Autoimmune and Cancer Diseases

    1. Front Matter
      Pages 199-199
    2. Trivendra Tripathi, Mohammed Shahid, Haris M. Khan, Mashiatullah Siddiqui, Aijaz Ahmed Khan, Rahat Ali Khan
      Pages 201-226
    3. Rajni Kant Shukla, Priyanka Jain, Sandeep Bhattacharya
      Pages 227-243
  8. Histamine Role in Inflammation and Allergy

    1. Front Matter
      Pages 245-245
    2. Ewa Brzezińska-Błaszczyk
      Pages 247-284
  9. Histamine in the Nervous System

    1. Front Matter
      Pages 297-297
    2. Aijaz Ahmed Khan, Trivendra Tripathi, Mohammed Shahid, Haris M. Khan, Rahat Ali Khan
      Pages 315-335
  10. Histamine H3 Receptor: A Target for Momentous Brain Research

    1. Front Matter
      Pages 337-337
    2. Angélica Osorio-Espinoza, Judith Ramos-Jiménez, José-Antonio Arias-Montaño
      Pages 339-368
  11. Histamine H4 Receptor: A Noble Target for Inflammatory and Immune Research

    1. Front Matter
      Pages 369-369
    2. Yoshiko Matsuda, Katsunori Yamaura, Masahiko Suzuki, Takao Namiki, Koichi Ueno
      Pages 371-379
  12. Role of Histamine in Reproductive Function

  13. Other Biomedical Aspects of Histamine Agonists, Antagonists, and Inverse Agonists

    1. Front Matter
      Pages 407-407
    2. Adil Raza, Haris M. Khan, Fatima Shujatullah
      Pages 409-420
    3. Trivendra Tripathi, Richa Pandey, Adil Raza, Mohammed Shahid, Haris M. Khan, Mashiatullah Siddiqui et al.
      Pages 421-436
  14. Back Matter
    Pages 437-441

About this book


Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas.

This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.


Histamine Histamine Antagonists Immunomodulators

Editors and affiliations

  • Nancy Khardori
    • 1
  • Rahat Ali Khan
    • 2
  • Trivendra Tripathi
    • 3
  1. 1.School of Medicine, Dept. Internal MedicineSouthern Illinois UniversitySpringfieldUSA
  2. 2.J. N. Medical College, Dept. PharmacologyAligarh Muslim UniversityAligarhIndia
  3. 3.Jawaharlal Nehru Medical College &, HospitalAligarh Muslim UniversityAligarhIndia

Bibliographic information