Viral Genome Replication

  • Kevin D. Raney
  • Matthias Gotte
  • Craig E.  Cameron

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Genome replication strategies

    1. Front Matter
      Pages 1-1
    2. Aniko V. Paul, George A. Belov, Ellie Ehrenfeld, Eckard Wimmer
      Pages 3-23
    3. Stanley G. Sawicki
      Pages 25-39
    4. Néstor G. Iglesias, Claudia V. Filomatori, Diego E. Alvarez, Andrea V. Gamarnik
      Pages 41-60
    5. Brett D. Lindenbach, Timothy L. Tellinghuisen
      Pages 61-88
    6. Guanghui Yi, C. Cheng Kao
      Pages 89-108
    7. Román Galetto, Matteo Negroni
      Pages 109-128
    8. John E. Tavis, Matthew P. Badtke
      Pages 129-143
    9. Sean P.J. Whelan
      Pages 145-162
    10. Paul Digard, Laurence Tiley, Debra Elton
      Pages 163-180
    11. Juan C. de la Torre
      Pages 181-200
    12. Sarah M. McDonald, John T. Patton
      Pages 201-224
    13. Kathleen Boyle, Paula Traktman
      Pages 225-247
    14. Sandra K. Weller
      Pages 249-265
    15. Peter D. Nagy, Judit Pogany
      Pages 267-295
    16. Mark D. Stenglein, April J. Schumacher, Rebecca S. LaRue, Reuben S. Harris
      Pages 297-334
  3. Elements, factors and enzymes: Structure-function and mechanism

    1. Front Matter
      Pages 1-1
    2. Scott W. Nelson, Zhihao Zhuang, Michelle M. Spiering, Stephen J. Benkovic
      Pages 337-364
    3. Shenping Liu, Fred L. Homa
      Pages 365-381
    4. Cristina Ferrer-Orta, Nuria Verdaguer
      Pages 383-401
    5. Michaela Wendeler, Jennifer T. Miller, Stuart F.J. Le Grice
      Pages 403-427
    6. Vaishnavi Rajagopal, Smita S. Patel
      Pages 429-466
    7. James Dolan, Jonathan Leis
      Pages 467-478
  4. Antivirals: Targets, mechanisms and resistance

    1. Front Matter
      Pages 479-479
    2. Graciela Andrei, Erik De Clercq, Robert Snoeck
      Pages 481-526
    3. Todd Appleby, I-hung Shih, Weidong Zhong
      Pages 527-548
    4. Bruno Marchand, Stefan G. Sarafianos
      Pages 549-570
    5. Kathleen Too, David Loakes
      Pages 571-587
    6. Kristel Van Laethem, Anne-Mieke Vandamme
      Pages 589-619
  5. Back Matter
    Pages 621-636

About this book


Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.


DNA HIV RNA Viruses enzymes infections polymer protein proteins regulation transcription virus

Editors and affiliations

  • Kevin D. Raney
  • Matthias Gotte
  • Craig E.  Cameron

There are no affiliations available

Bibliographic information