Regression Methods in Biostatistics

Linear, Logistic, Survival, and Repeated Measures Models

  • Eric Vittinghoff
  • Stephen C. Shiboski
  • David V. Glidden
  • Charles E. McCulloch

Part of the Statistics for Biology and Health book series (SBH)

Table of contents

  1. Front Matter
    Pages I-XV
  2. Pages 1-5
  3. Pages 69-131
  4. Pages 133-156
  5. Pages 157-209
  6. Pages 211-252
  7. Pages 305-316
  8. Pages 317-322
  9. Back Matter
    Pages 323-340

About this book


This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes.

Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way.

The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided. For many students and researchers learning to use these methods, this one book may be all they need to conduct and interpret multipredictor regression analyses.

The authors are on the faculty in the Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, and are authors or co-authors of more than 200 methodological as well as applied papers in the biological and biomedical sciences. The senior author, Charles E. McCulloch, is head of the Division and author of Generalized Linear Mixed Models (2003), Generalized, Linear, and Mixed Models (2000), and Variance Components (1992).


Generalized linear model Logistic Regression Regression analysis Stata Survival analysis Variance applied regression methods for biomedical research confounding, mediation, and interaction data analysis linear regression linear, logistic, generalized linear, survival (Cox), GEE, a model selection and checking statistical computing with STATA statistics

Authors and affiliations

  • Eric Vittinghoff
    • 1
  • Stephen C. Shiboski
    • 1
  • David V. Glidden
    • 1
  • Charles E. McCulloch
    • 1
  1. 1.Department of Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA

Bibliographic information