Development and Engineering of Dopamine Neurons

  • R. Jeroen Pasterkamp
  • Marten P. Smidt
  • J. Peter H. Burbach

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 651)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Jörn Schweitzer, Wolfgang Driever
    Pages 1-14
  3. John W. Cave, Harriet Baker
    Pages 15-35
  4. Antonio Simeone, Eduardo Puelles, Dario Acampora, Daniela Omodei, Pietro Mancuso, Luca Giovanni Di Giovannantonio
    Pages 36-46
  5. Marten P. Smidt, J. Peter, H. Burbach
    Pages 47-57
  6. Horst H. Simon, Kambiz N. Alavian
    Pages 66-72
  7. Oliver von Bohlen, Klaus Unsicker
    Pages 73-80
  8. Eleni Roussa, Oliver von Bohlen und Halback, Kerstin Krieglstein
    Pages 81-90
  9. Asheeta A. Prasad, R. Jeroen Pasterkamp
    Pages 91-100
  10. Sonja Kriks, Lorenz Studer
    Pages 101-111
  11. Back Matter
    Pages 125-127

About this book


Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.


Nervous System Parkinson forebrain neurons neuroscience

Editors and affiliations

  • R. Jeroen Pasterkamp
    • 1
  • Marten P. Smidt
    • 1
  • J. Peter H. Burbach
    • 1
  1. 1.Rudolf Magnus Institute of Neuroscience Department of Neuroscience and PharmacologyUniversity Medical Center UtrechtUtrechtThe Netherlands

Bibliographic information