Diabetic Nephropathy

Strategy for Therapy

  • Eli A. Friedman
  • Charles M. Peterson

Part of the Developments in Nephrology book series (DINE, volume 9)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Charles M. Peterson, Lois Jovanovic
    Pages 1-8
  3. Charles M. Peterson, Lois Jovanovic
    Pages 9-32
  4. Charles M. Peterson, Lois Jovanovic
    Pages 33-40
  5. Francis A. L’esperance Jr
    Pages 41-64
  6. Eli A. Friedman
    Pages 65-83
  7. Kathleen Y. Whitley, Fred L. Shapiro
    Pages 85-103
  8. Ramesh Khanna, Dimitrios G. Oreopoulos
    Pages 105-138
  9. David E. R. Sutherland, John S. Najarian
    Pages 155-177
  10. Charles M. Peterson, Lois Jovanovic
    Pages 187-193
  11. Mildred Friedman
    Pages 213-221
  12. Eli A. Friedman
    Pages 223-229
  13. Back Matter
    Pages 231-254

About this book


Diabetic nephropathy is a tragic illness. Its often insidious onset in the insulin­ dependent (type I) diabetic, typically a young adult, heralds the last act in the course of a disease that will increasingly become the dominant preoccupation in the patient's shortened life. For most type II diabetics, the beginning of clinical renal insufficiency is but a phase in a continuous deterioration that affects the integrity ofjob, marriage, and family. The nephropathic diabetic is hypertensive, has worsening retinopathy, and more often than not, is also plagued by peripheral vascular insufficiency, heart disease, gastrointestinal malfunction, and deepening depression. Until the 1980's, few type I diabetics who became uremic (because ofdiabetic nephropathy) lived for more than two years. Hardly any attained true rehabilitation. This dismal prognosis is changing substantially for the better. Research in diabetes has resulted in striking advances at both ends of the type I diabetic's natural history. In one exciting clinical trial now underway in London, Ontario, halfofchildhood diabetics treated with cyclosporine within six weeks of onset evince"permanent" disappearanceofhyperglycemia and the need for insulin. At the otherendofthe natural historyofdiabetes for the nephropathic patientwith worsening eye disease (renal-retinal syndrome), who receives a kidney transplant, patient and graft survival, two years after cadaveric kidney transplantation in type I diabetics is now equal to that of the nondiabetic.


Insulin diabetes kidney transplantation

Editors and affiliations

  • Eli A. Friedman
    • 1
  • Charles M. Peterson
    • 2
  1. 1.Division of Renal DiseaseState University of New York, Downstate Medical CenterBrooklynUSA
  2. 2.Sansum Medical Research FoundationSanta BarbaraUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-9410-8
  • Online ISBN 978-1-4613-2287-0
  • Buy this book on publisher's site