Thyroid and Heart

A Comprehensive Translational Essay

  • Giorgio Iervasi
  • Alessandro Pingitore
  • A.Martin Gerdes
  • Salman Razvi

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Heart and Thyroid: Historical and Basic Aspects

    1. Front Matter
      Pages 1-1
    2. José Augusto Sgarbi
      Pages 3-11
    3. Grazia Rutigliano, Giorgio Iervasi
      Pages 13-22
    4. Kaie Ojamaa, Maria Alicia Carrillo-Sepulveda
      Pages 23-41
  3. Cardiac Metabolism and Function in Thyroid Disorders

  4. Thyroid System in CV Diseases in Experimental Models

    1. Front Matter
      Pages 69-69
    2. Claudia Kusmic, Serena L’Abbate
      Pages 71-83
    3. Federica Saponaro, Riccardo Zucchi
      Pages 97-107
    4. Francesca Forini, Letizia Pitto, Giuseppina Nicolini
      Pages 109-126
    5. Silvana Balzan, Valter Lubrano
      Pages 127-136
    6. Viswanathan Rajagopalan, A. Martin Gerdes
      Pages 137-152
    7. Constantinos Pantos
      Pages 153-162
    8. Melania Gaggini, Irene Traghella, Cristina Vassalle
      Pages 171-186
    9. Aleksander Kuś, Alexander Teumer, Layal Chaker, Marco Medici
      Pages 187-202
  5. Heart and Thyroid in Clinics

    1. Front Matter
      Pages 203-203
    2. Wendy P. J. den Elzen, Simon P. Mooijaart, Bart E. P. B. Ballieux, Anne R. Cappola, Jacobijn Gussekloo
      Pages 205-227
    3. Bernadette Biondi
      Pages 229-237
    4. Avais Jabbar, Salman Razvi
      Pages 239-243
    5. Gabriela Brenta, Laura Schreier
      Pages 245-262
    6. Sonia Marrakchi Meziou, Emna Bennour, Faouzi Kanoun, Dania Idriss Marrakchi, Ikram Kammoun, Salem Kachboura
      Pages 263-277
    7. Dimitrios Varvarousis, Stavros Chryssanthopoulos, Kali Polytarchou, Dennis V. Cokkinos
      Pages 279-299
    8. Michele Emdin, Andrea Barison, Alberto Aimo
      Pages 301-309
    9. Fausto Bogazzi, Daniele Cappellani
      Pages 311-325
    10. Carmine Zoccali, Francesca Mallamaci
      Pages 327-338
    11. Julius Burkauskas, Aiste Pranckeviciene, Adomas Bunevicius
      Pages 339-360
  6. TH Treatment in Cardiac Disorders: Current and New Perspectives

    1. Front Matter
      Pages 361-361
    2. Alessandro Pingitore, Francesca Mastorci
      Pages 391-407
    3. Dimitri Novitzky, David K. C. Cooper
      Pages 409-436

About this book


In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely.
This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The  section devoted to the potential  therapeutic treatments has been expanded. 
Thanks to its translational approach to this highly complex subject, the book will be  of interest to a broad readership, including cardiologists, endocrinologists and internists. 


Thyroid Hormone Heart Failure Thyroid metabolism Left ventricular function and morphology Left ventricular remodelling Thyroid replacement therapy Prognosis

Editors and affiliations

  • Giorgio Iervasi
    • 1
  • Alessandro Pingitore
    • 2
  • A.Martin Gerdes
    • 3
  • Salman Razvi
    • 4
  1. 1.Institute of Clinical Physiology (IFC) National Research Council (CNR)PisaItaly
  2. 2.Institute of Clinical Physiology (IFC) National Research Council (CNR)PisaItaly
  3. 3.NYITCOM College of Osteopathic Medicine Biomedical Sciences DepartmentOld WestburyUSA
  4. 4.Institute of Clinical and Translational Medicine, Newcastle University/Queen Elizabeth HospitalNewcastle upon TyneUK

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-030-36870-8
  • Online ISBN 978-3-030-36871-5
  • Buy this book on publisher's site