Management of Severe Skin Eruptions

  • Katherine Menson
  • Garth W. GarrisonEmail author


Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a continuum of severe mucocutaneous eruptions associated with significant morbidity. The condition is characterized by diffuse erythematous purpuric macules or flat targetoid lesions that evolve into vesicles and bullae followed by skin sloughing. The skin changes are nearly always associated with mucosal involvement. SJS/TEN is typically induced by medication use, but can be triggered by bacterial or viral infections. Management involves removal of the offending agent and supportive care. The evidence supporting corticosteroids and IVIG is lacking, although evidence of new therapies is emerging. In this chapter, the diagnosis and management of SJS/TEN will be discussed. The conflicting data on systemic therapy is addressed.


Stevens-Johnson syndrome SJS Toxic epidermal necrolysis TEN Skin eruption Blister Drug reaction Drug rash 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Pulmonary & Critical Care MedicineUniversity of Vermont Medical CenterBurlingtonUSA

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