Primary Sclerosing Cholangitis

  • Christian SchäferEmail author
  • Jörg G. Albert


Primary sclerosing cholangitis (PSC) is an inflammatory disease of the bile duct system that is mainly associated with ulcerative colitis and Crohn’s disease. PSC may be complicated by progressive cholestasis, cirrhosis and liver failure. So far, there is no cure of the disease and medical treatment may alter the course of the disease without significant improvement of prognosis. In selected patients with a dominant stricture of the CBD or any of the hepatic ducts, endoscopic dilation may significantly reduce jaundice and ameliorate pruritus. A major concern is the occurrence of cholangiocarcinoma in PSC. Brush cytology and/or cholangioscopy with targeted biopsies may contribute to early detection of malignant lesions.


Cholangiocarcinoma Primary sclerosing cholangitis IgG4-associated cholangitis Eosinophilic cholangitis Ursodeoxycholic acid ERCP Dilation Dominant stricture 



Autoimmune hepatitis


European Association for the Study of the Liver


Eosinophilic cholangitis


Endoscopic retrograde cholangiopancreatography


European Society of Gastrointestinal Endoscopy


IgG4-associated cholangitis


Inflammatory bowel disease


Liver function test


Magnetic resonance cholangiopancreatography


Primary sclerosing cholangitis


Ursodeoxycholic acid


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Abteilung für Gastroenterologie, Hepatologie und EndokrinologieRobert-Bosch-KrankenhausStuttgartGermany

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