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Primary Sclerosing Cholangitis

  • Christian SchäferEmail author
  • Jörg G. Albert
Chapter
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Abstract

Primary sclerosing cholangitis (PSC) is an inflammatory disease of the bile duct system that is mainly associated with ulcerative colitis and Crohn’s disease. PSC may be complicated by progressive cholestasis, cirrhosis and liver failure. So far, there is no cure of the disease and medical treatment may alter the course of the disease without significant improvement of prognosis. In selected patients with a dominant stricture of the CBD or any of the hepatic ducts, endoscopic dilation may significantly reduce jaundice and ameliorate pruritus. A major concern is the occurrence of cholangiocarcinoma in PSC. Brush cytology and/or cholangioscopy with targeted biopsies may contribute to early detection of malignant lesions.

Keywords

Cholangiocarcinoma Primary sclerosing cholangitis IgG4-associated cholangitis Eosinophilic cholangitis Ursodeoxycholic acid ERCP Dilation Dominant stricture 

Abbreviations

AIH

Autoimmune hepatitis

EASL

European Association for the Study of the Liver

EOC

Eosinophilic cholangitis

ERCP

Endoscopic retrograde cholangiopancreatography

ESGE

European Society of Gastrointestinal Endoscopy

IAC

IgG4-associated cholangitis

IBD

Inflammatory bowel disease

LFT

Liver function test

MRCP

Magnetic resonance cholangiopancreatography

PSC

Primary sclerosing cholangitis

UDCA

Ursodeoxycholic acid

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Abteilung für Gastroenterologie, Hepatologie und EndokrinologieRobert-Bosch-KrankenhausStuttgartGermany

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