Transcranial Direct Current Stimulation for the Treatment of Hallucinations in Patients with Schizophrenia

  • Jérôme BrunelinEmail author
  • Emmanuel Poulet


Around 25–30% of patients with schizophrenia report auditory verbal hallucinations (AVH) that fail to respond sufficiently to antipsychotic treatments. In such cases, transcranial direct current stimulation (tDCS) has been proposed as a therapeutic solution. Here, we aim to provide a review of randomized controlled trials (RCTs) examining the clinical effects of tDCS on AVH in patients with schizophrenia. Results from 11 available RCTs on the PubMed and web of science databases suggest that a suitable approach for decreasing AVH was to deliver at least twice-daily sessions of tDCS over 5 consecutive days (10 sessions at 20 min each, 2 mA) with the anode over the left dorsolateral prefrontal cortex and the cathode over the left temporoparietal junction. Further RCTs, with large sample sizes, are needed to confirm the usefulness of tDCS for AVH.


Schizophrenia Auditory hallucinations Neuromodulation tDCS Brain stimulation 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.INSEINSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, PSYR2 TeamLyonFrance
  2. 2.University Lyon 1VilleurbanneFrance
  3. 3.Centre Hospitalier Le VinatierBronFrance

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