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Physiology of the Pineal Gland

  • Alexis Rafael Narváez-Rojas
  • Luis R. Moscote-Salazar
  • Ali A. Dolachee
  • Mohammed Ameen Alrawi
  • Ali M. Neamah
  • Saja A. AlBanaa
Chapter
  • 35 Downloads

Abstract

The descriptions of the pineal gland go back to antiquity, but its functions in humans are little known. The PG has a principal action of secreting hormones, mainly the melatonin. Melatonin is secreted according to the presence of stimuli from the external environment through light changes. New advances in the physiology of the pineal gland are the molecular description of melatonin receptors. The physiological significance of pineal characters other than melatonin and pineal peptides has not yet been thoroughly understood.

Keywords

Physiology Melatonin Molecular Pineal Light Night 

References

  1. 1.
    Sugden D. Melatonin biosynthesis in the mammalian pineal gland. Experientia. 1989;45(10):922–32.CrossRefGoogle Scholar
  2. 2.
    Arendt J. Melatonin: characteristics, concerns, and prospects. J Biol Rhythm. 2005;20(4):291–303.CrossRefGoogle Scholar
  3. 3.
    Benitez-King G, Anton-Tay F. Calmodulin mediates melatonin cytoskeletal effects. Experientia. 1993;49(8):635–41.CrossRefGoogle Scholar
  4. 4.
    Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A. A review of melatonin, its receptors and drugs. Eurasian J Med. 2016;48(2):135.CrossRefGoogle Scholar
  5. 5.
    Pévet P. Melatonin receptors as therapeutic targets in the suprachiasmatic nucleus. Expert Opin Ther Targets. 2016;20(10):1209–18.CrossRefGoogle Scholar
  6. 6.
    Al-Ghoul WM, Herman MD, Dubocovich ML. Melatonin receptor subtype expression in human cerebellum. Neuroreport. 1998;9(18):4063–8.CrossRefGoogle Scholar
  7. 7.
    Bergiannaki JD, Soldatos CR, Paparrigopoulos TJ, Syrengelas M, Stefanis CN. Low and high melatonin excretors among healthy individuals. J Pineal Res. 1995;18(3):159–64.CrossRefGoogle Scholar
  8. 8.
    James O. In: Olcese J, editor. Melatonin after four decades. Boston, MA: Springer; 2002.Google Scholar
  9. 9.
    Pangerl B, Pangerl A, Reiter RJ. Circadian variations of adrenergic receptors in the mammalian pineal gland: a review. J Neural Transm. 1990;81(1):17–29.CrossRefGoogle Scholar
  10. 10.
    Borjigin J, Wang MM, Snyder SH. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Nature. 1995;378(6559):783.CrossRefGoogle Scholar
  11. 11.
    Burgess HJ, Trinder J, Kim Y, Luke D. Sleep and circadian influences on cardiac autonomic nervous system activity. Am J Phys Heart Circ Phys. 1997;273(4):H1761–8.Google Scholar
  12. 12.
    Attanasio A, Borrelli P, Gupta D. Circadian rhythms in serum melatonin from infancy to adolescence. J Clin Endocrinol Metab. 1985;61(2):388–90.CrossRefGoogle Scholar
  13. 13.
    Blask DE, Lemus-Wilson AM, Wilson ST. Breast cancer: a model system for studying the neuroendocrine role of pineal melatonin in oncology. Biochem Soc Trans. 1992;20(2):309–11.CrossRefGoogle Scholar
  14. 14.
    Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K. Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis. Int J Mol Sci. 2017;18(4):843.CrossRefGoogle Scholar
  15. 15.
    Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, Herer P, Tzischinsky O, Lavie P. Sleep disorders and melatonin rhythms in elderly people. BMJ. 1994;309(6948):167.CrossRefGoogle Scholar
  16. 16.
    Dawson D, Encel N. Melatonin and sleep in humans. J Pineal Res. 1993;15(1):1–2.CrossRefGoogle Scholar
  17. 17.
    Laudon M, Frydman-Marom A. Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders. Int J Mol Sci. 2014;15(9):15924–50.CrossRefGoogle Scholar
  18. 18.
    Berga SL, Mortola JF, Yen SS. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab. 1988;66(1):242–4.CrossRefGoogle Scholar
  19. 19.
    Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S. Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythm. 1997;12(6):604–17.CrossRefGoogle Scholar
  20. 20.
    Pacchierotti C, Iapichino S, Bossini L, Pieraccini F, Castrogiovanni P. Melatonin in psychiatric disorders: a review on the melatonin involvement in psychiatry. Front Neuroendocrinol. 2001;22(1):18–32.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Alexis Rafael Narváez-Rojas
    • 1
  • Luis R. Moscote-Salazar
    • 2
  • Ali A. Dolachee
    • 3
  • Mohammed Ameen Alrawi
    • 4
  • Ali M. Neamah
    • 5
  • Saja A. AlBanaa
    • 5
  1. 1.Department of SurgeryCarlos Roberto Huembes HospitalManaguaNicaragua
  2. 2.Department of Neurosurgery, Cartagena Neurotrauma Research Group (CIB)University of CartagenaBolívarColombia
  3. 3.Department of SurgeryCollege of Medicine, University of Al-QadisiyahDiwaniyahIraq
  4. 4.Department of NeurosurgeryNeurosurgery Teaching HospitalBaghdadIraq
  5. 5.College of MedicineUniversity of BaghdadBaghdadIraq

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