Interesting Cases of Pineal Gland Diseases and Surgery

  • Gobran Taha Al-Fotih
  • Samer S. Hoz


The diversity of pineal gland lesions implies frequent emergence of relatively unexpected presentations, pathologies, complications, or even recurrences. Studying the spectrum of pineal diseases and their management necessitates knowledge of reported cases which are rare, whether in terms of having unusual presentation, pathologies, or disease course, as this might ultimately lead to improved patient survival and overall outcome.


Pineal Parkinsonism Germinoma Lesions Schwannoma Craniopharyngioma 



Professor Marcos Tatagiba (Germany) and Professor FangCheng Li (China) for their support and valuable advices during the writing of this chapter.


  1. 1.
    Kondo T. Brain tumor and parkinsonism. Nihon rinsho. Japan J Clin Med. 1997;55(1):118–22.Google Scholar
  2. 2.
    Wakai S, Nakamura K, Niizaki K, Nagai M, Nishizawa T, Yokoyama S, Katayama S. Meningioma of the anterior third ventricle presenting with parkinsonism. Surg Neurol. 1984;21(1):88–92.CrossRefGoogle Scholar
  3. 3.
    de Vera Reyes JA. Parkinsonian-like syndrome caused by posterior fossa tumor: case report. J Neurosurg. 1970;33(5):599–601.CrossRefGoogle Scholar
  4. 4.
    Syndyk R, Khan I. Parkinsonism due to subdural hematoma. J Neurosurg. 1993;58:298–9.CrossRefGoogle Scholar
  5. 5.
    Vhora S, Kobayashi S, Okudera H. Pineal cavernous angioma presenting with parkinsonism. J Clin Neurosci. 2001;8(3):263–6.CrossRefGoogle Scholar
  6. 6.
    Dolendo MC, Lin TP, Tat OH, Chong QT, Timothy LK. Parkinsonism as an unusual presenting symptom of pineal gland teratoma. Pediatr Neurol. 2003;28(4):310–2.CrossRefGoogle Scholar
  7. 7.
    Shivashankar N, Shashikala HR, Nagaraja D, Jayakumar PN, Ratnavalli E. Pure word deafness in two patients with subcortical lesions. Clin Neurol Neurosurg. 2001;103(4):201–5.CrossRefGoogle Scholar
  8. 8.
    Joswig H, Schönenberger U, Brügge D, Richter H, Surbeck W. Reversible pure word deafness due to inferior colliculi compression by a pineal germinoma in a young adult. Clin Neurol Neurosurg. 2015;139:62–5.CrossRefGoogle Scholar
  9. 9.
    Ide M, Jimbo M, Yamamoto M, Hagiwara S, Aiba M, Kubo O. Spontaneous regression of primary intracranial germinoma: a case report. Cancer. 1997;79(3):558–63.CrossRefGoogle Scholar
  10. 10.
    Mattogno PP, Frassanito P, Massimi L, Tamburrini G, Novello M, Lauriola L, Caldarelli M. Spontaneous regression of pineal lesions: ghost tumor or pineal apoplexy? World Neurosurg. 2016;88:64–9.CrossRefGoogle Scholar
  11. 11.
    Chaudhry NS, Ahmad FU, Morcos JJ. Pineal region schwannoma arising from the trochlear nerve. J Clin Neurosci. 2016;32:159–61.CrossRefGoogle Scholar
  12. 12.
    Usanov EI, Hatomkin DM, Nikulina TA, Gorban NA. Craniopharyngioma of the pineal region. Childs Nerv Syst. 1999;15(1):4–7.CrossRefGoogle Scholar
  13. 13.
    Loeffler JS, Ervin TJ, Mauch P, Skarin A, Weinstein HJ, Canellos G, Cassady JR. Primary lymphomas of the central nervous system: patterns of failure and factors that influence survival. J Clin Oncol. 1985;3(4):490–4.CrossRefGoogle Scholar
  14. 14.
    Hollender A, Kvaloy S, Lote K, Nome O, Holte H. Prognostic factors in 140 adult patients with non-Hodgkin’s lymphoma with systemic central nervous system (CNS) involvement. A single Centre analysis. Eur J Cancer. 2000;36(14):1762–8.CrossRefGoogle Scholar
  15. 15.
    Gadó K, Pállinger E, Kovács P, Takács E, Szilvási I, Tóth BE, Nagy G, Domján G, Falus A. Prolactin influences proliferation and apoptosis of a human IgE secreting myeloma cell line, U266. Immunol Lett. 2002;82(3):191–6.CrossRefGoogle Scholar
  16. 16.
    Kim YJ, Kim HK, Yang DH, Jung S, Noh MG, Lee JH, Lee KH, Moon KS. Pineal diffuse large B-Cell lymphoma concomitant with pituitary prolactinoma: possible correlation between 2 distinguished pathologies: a case report. Medicine. 2016;95(8):e2923.CrossRefGoogle Scholar
  17. 17.
    Choi BK, Cha SH, Song GS, Choi CH, Lee SW, Lim YT, Kim WT. Recurrent intracranial germinoma along the endoscopic ventriculostomy tract: case report. J Neurosurg Pediatr. 2007;107(1):62–5.CrossRefGoogle Scholar
  18. 18.
    MacKay CI, Baeesa SS, Ventureyra EC. Epidermoid cysts of the pineal region. Childs Nerv Syst. 1999;15(4):170–8.CrossRefGoogle Scholar
  19. 19.
    Pagni F, Brenna A, Leone BE, Vergani F, Isimbaldi G. Malignant epidermoid cyst of the pineal region with lumbar metastasis. Neuropathology. 2007;27(6):566–9.CrossRefGoogle Scholar
  20. 20.
    Walker AJ, Huynh-Le MP, Nauen D, Malayeri AA, Jallo G, Terezakis SA. Intracranial germinoma in the pineal region arising after subtotal resection of epidermoid cyst: case report. Childs Nerv Syst. 2014;30(5):963–6.CrossRefGoogle Scholar
  21. 21.
    Birbilis TA, Matis GK, Eleftheriadis SG, Theodoropoulou EN, Sivridis E. Spinal metastasis of glioblastoma multiforme: an uncommon Lacroix M, Abi-said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F, Lang FF, McCutcheon IE, Hassenbusch SJ, Holland E, Hess K. a multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95(2):190–8.CrossRefGoogle Scholar
  22. 22.
    Kamoshima Y, Sawamura Y, Ikeda J, Shirato H, Aoyama H. Late recurrence and salvage therapy of CNS germinomas. J Neuro-Oncol. 2008;90(2):205.CrossRefGoogle Scholar
  23. 23.
    Mano Y, Kanamori M, Kumabe T, Saito R, Watanabe M, Sonoda Y, Tominaga T. Extremely late recurrence 21 years after total removal of immature teratoma: a case report and literature review. Neurol Med Chir (Tokyo). 2017;57(1):51–6.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Gobran Taha Al-Fotih
    • 1
  • Samer S. Hoz
    • 2
  1. 1.Department of NeurosurgeryAl-Thawra Modern General HospitalSana’aYemen
  2. 2.Neurosurgery Teaching HospitalBaghdadIraq

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