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Upper Gastrointestinal Cancers

  • Vivek Verma
  • Ethan B. LudmirEmail author
  • Faisal Siddiqui
  • Celine Bicquart Ord
  • Charles R. ThomasJr.
Chapter
  • 31 Downloads

Abstract

The landscape of treatment paradigms for upper gastrointestinal tract malignancies, including hepatobiliary and pancreatic cancers, is rapidly evolving. Changing regimens, including the role of preoperative and perioperative therapies, are emerging, supported by prospective data. Here, we review the most recent literature with regard to the role of radiotherapy for upper gastrointestinal malignancies, including in the treatment of esophageal, gastric, pancreatic, and hepatobiliary cancers. The role of stereotactic body radiotherapy, particularly in the treatment of both pancreatic and hepatic malignancies, is mentioned as well. Data supporting the role of preoperative chemoradiation for esophageal cancer are reviewed, as is the complex milieu of literature surrounding the role of radiotherapy for primary gastric and pancreatic malignancies. Collectively, this chapter aims to highlight and emphasize the most critical and up-to-date information in the treatment of upper gastrointestinal malignancies for radiation oncologists.

Keywords

Esophageal cancer Pancreatic cancer Gastric cancer Hepatocellular carcinoma Cholangiocarcinoma Preoperative therapy Perioperative therapy Stereotactic body radiotherapy 

Copyright information

© Springer Nature Switzerland AG 2021

Authors and Affiliations

  • Vivek Verma
    • 1
  • Ethan B. Ludmir
    • 1
    Email author
  • Faisal Siddiqui
    • 2
  • Celine Bicquart Ord
    • 3
  • Charles R. ThomasJr.
    • 4
  1. 1.Department of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Compass OncologyVancouverUSA
  3. 3.Carson Tahoe Radiation Oncology AssociatesCarson CityUSA
  4. 4.Department of Radiation MedicineOregon Health Science UniversityPortlandUSA

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