Upper Gastrointestinal Cancers
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The landscape of treatment paradigms for upper gastrointestinal tract malignancies, including hepatobiliary and pancreatic cancers, is rapidly evolving. Changing regimens, including the role of preoperative and perioperative therapies, are emerging, supported by prospective data. Here, we review the most recent literature with regard to the role of radiotherapy for upper gastrointestinal malignancies, including in the treatment of esophageal, gastric, pancreatic, and hepatobiliary cancers. The role of stereotactic body radiotherapy, particularly in the treatment of both pancreatic and hepatic malignancies, is mentioned as well. Data supporting the role of preoperative chemoradiation for esophageal cancer are reviewed, as is the complex milieu of literature surrounding the role of radiotherapy for primary gastric and pancreatic malignancies. Collectively, this chapter aims to highlight and emphasize the most critical and up-to-date information in the treatment of upper gastrointestinal malignancies for radiation oncologists.