Future Trends of 3D Guidance in Dentistry

  • Niraj KinariwalaEmail author
  • Lakshman Samaranayake
  • Gunpreet Oberoi
  • Hermann Agis


This chapter encompasses technological advancements in field of dentistry including use of three-dimensional (3D) printing in autotransplantation, 3D printing in smile designing, future of bioprinting technology, and haptic virtual reality in endodontics.


Autotransplantation 3D printing Bioprinting Virtual reality Haptic simulation in endodontics 


  1. 1.
    Andreasen JO. Interrelation between alveolar bon and periodontal ligament repair after replantation of mature permanent incisors in monkeys. J Periodontal Res. 1981;16:228–35.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Hupp JG, Mesaros SV, Aukhil I, Trope M. Periodontal ligament vitality and histologic healing of teeth stored for extended periods before transplantation. Endod Dent Traumatol. 1998;14:79–83.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Andreasen JO. Periodontal healing after replantation and autotransplantation of incisors in monkeys. Int J Oral Surg. 1981;10:54–61.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Lee SJ, Kim E. Minimizing the extra-oral time in autogeneous tooth transplantation: use of computer-aided rapid prototyping (CARP) as a duplicate model tooth. Restor Dent Endod. 2012;37(3):136–41.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Lee SJ, Jung IY, Lee CY, et al. Clinical application of computer-aided rapid prototyping for tooth transplantation. Dent Traumatol. 2001;17:114–9.PubMedCrossRefPubMedCentralGoogle Scholar
  6. 6.
    Jang Y, Choi YJ, Lee SJ, et al. Prognostic factors for clinical outcomes in autotransplantation of teeth with complete root formation: survival analysis for up to 12 years. J Endod. 2016;42:198–205.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Mejàre B, Wannfors K, Jansson L. A prospective study on transplantation of third molars with complete root formation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:231–8.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Nethander G, Andersson JE, Hirsch JM. Autogenous free tooth transplantation in man by a 2-stage operation technique. A longitudinal intra-individual radiographic assessment. Int J Oral Maxillofac Surg. 1988;17:330–6.PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    Schwartz O, Bergmann P, Klausen B. Autotransplantation of human teeth. A life-table analysis of prognostic factors. Int J Oral Surg. 1985;14:245–58.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Jang JH, Lee SJ, Kim E. Autotransplantation of immature third molars using a computer-aided rapid prototyping model: a report of 4 cases. J Endod. 2013;39:1461–6.PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Oh S, Kim S, et al. Virtual simulation of autotransplantation using 3-dimensional printing prototyping model and computer-assisted design program. J Endod. 2018;44:1883–8.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Goldberg M, editor. The dental pulp: biology, pathology, and regenerative therapies. New York, NY: Springer; 2014.Google Scholar
  13. 13.
    Shi Y, Inoue H, Wu JC, Yamanaka S. Induced pluripotent stem cell technology: a decade of progress. Nat Rev Drug Discov. 2017;16(2):115–30.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Yin JQ, Zhu J, Ankrum JA. Manufacturing of primed mesenchymal stromal cells for therapy. Nat Biomed Eng. 2019;3(2):90–104.PubMedCrossRefPubMedCentralGoogle Scholar
  15. 15.
    Yu H, Zhang X, Song W, Pan T, Wang H, Ning T, et al. Effects of 3-dimensional bioprinting alginate/gelatin hydrogel scaffold extract on proliferation and differentiation of human dental pulp stem cells. J Endod. 2019;45(6):706–15.PubMedCrossRefPubMedCentralGoogle Scholar
  16. 16.
    Pilipchuk SP, Monje A, Jiao Y, Hao J, Kruger L, Flanagan CL, et al. Integration of 3D printed and micropatterned polycaprolactone scaffolds for guidance of oriented collagenous tissue formation in vivo. Adv Healthc Mater. 2016;5(6):676–87.PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Ruangsawasdi N, Zehnder M, Weber FE. Fibrin gel improves tissue ingrowth and cell differentiation in human immature premolars implanted in rats. J Endod. 2014;40(2):246–50.PubMedCrossRefPubMedCentralGoogle Scholar
  18. 18.
    Kakarla P, Avula JSS, Mellela GM, Bandi S, Anche S. Dental pulp response to collagen and pulpotec cement as pulpotomy agents in primary dentition: a histological study. J Conserv Dent. 2013;16(5):434–8.PubMedPubMedCentralCrossRefGoogle Scholar
  19. 19.
    Kikuchi N, Kitamura C, Morotomi T, Inuyama Y, Ishimatsu H, Tabata Y, et al. Formation of dentin-like particles in dentin defects above exposed pulp by controlled release of fibroblast growth factor 2 from gelatin hydrogels. J Endod. 2007;33(10):1198–202.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Suzuki T, Lee CH, Chen M, Zhao W, Fu SY, Qi JJ, et al. Induced migration of dental pulp stem cells for in vivo pulp regeneration. J Dent Res. 2011;90(8):1013–8.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Cvikl B, Hess SC, Miron RJ, Agis H, Bosshardt D, Attin T, et al. Response of human dental pulp cells to a silver-containing PLGA/TCP-nanofabric as a potential antibacterial regenerative pulp-capping material. BMC Oral Health. 2017;17(1):57.PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. J Endod. 2007;33(4):377–90.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Agis H, Beirer B, Watzek G, Gruber R. Effects of carboxymethylcellulose and hydroxypropylmethylcellulose on the differentiation and activity of osteoclasts and osteoblasts. J Biomed Mater Res A. 2010;95(2):504–9.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Xu HH, Wang P, Wang L, Bao C, Chen Q, Weir MD, et al. Calcium phosphate cements for bone engineering and their biological properties. Bone Res. 2017;5:17056.PubMedPubMedCentralCrossRefGoogle Scholar
  25. 25.
    Li J, Chen M, Wei X, Hao Y, Wang J. Evaluation of 3D-printed polycaprolactone scaffolds coated with freeze-dried platelet-rich plasma for bone regeneration. Materials (Basel). 2017;10(7):e831.CrossRefGoogle Scholar
  26. 26.
    Yan M, Yu Y, Zhang G, Tang C, Yu J. A journey from dental pulp stem cells to a bio-tooth. Stem Cell Rev. 2011;7(1):161–71.CrossRefGoogle Scholar
  27. 27.
    Redwood B, Schöffer F, Garret B. The 3d printing handbook: technologies, design and applications. 1st ed. Amsterdam: 3d Hubs; 2017.Google Scholar
  28. 28.
    Ozbolat IT, Moncal KK, Gudapati H. Evaluation of bioprinter technologies. Addit Manufac. 2017;13:179–200.CrossRefGoogle Scholar
  29. 29.
    Ozbolat IT, Peng W, Ozbolat V. Application areas of 3D bioprinting. Drug Discov Today. 2016;21(8):1257–71.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR. Organ printing: tissue spheroids as building blocks. Biomaterials. 2009;30(12):2164–74.PubMedPubMedCentralCrossRefGoogle Scholar
  31. 31.
    Oberoi G, Janjić K, Müller AS, Schädl B, Andrukhov O, Moritz A, et al. Contraction dynamics of rod microtissues of gingiva-derived and periodontal ligament-derived cells. Front Physiol. 2018;9:1683.PubMedPubMedCentralCrossRefGoogle Scholar
  32. 32.
    Oberoi G, Janjić K, Müller AS, Schädl B, Moritz A, Agis H. Contraction dynamics of dental pulp cell rod microtissues. Clin Oral Investig. 2020;24:631.PubMedCrossRefPubMedCentralGoogle Scholar
  33. 33.
    Ji S, Guvendiren M. Recent advances in bioink design for 3D bioprinting of tissues and organs. Front Bioeng Biotechnol. 2017;5:23.PubMedPubMedCentralCrossRefGoogle Scholar
  34. 34.
    Blakely AM, Manning KL, Tripathi A, Morgan JR. Bio-pick, place, and perfuse: a new instrument for three-dimensional tissue engineering. Tissue Eng Part C Methods. 2015;21(7):737–46.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Morgan AJL, Hidalgo San Jose L, Jamieson WD, Wymant JM, Song B, Stephens P, et al. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS One. 2016;11(4):e0152023.PubMedPubMedCentralCrossRefGoogle Scholar
  36. 36.
    Pontons-Melo JC, Furuse AY, Mondelli J. A direct composite resin stratification technique for restoration of the smile. Quintessence Int. 2011;42(3):205–11.PubMedPubMedCentralGoogle Scholar
  37. 37.
    Wong NK, Kassim AA, Foong KW. Analysis of esthetic smiles by using computer vision techniques. Am J Orthod Dentofac Orthop. 2005;128(3):404–11.CrossRefGoogle Scholar
  38. 38.
    Rosati R, De Menezes M, Rossetti A, Sforza C, Ferrario VF. Digital dental cast placement in 3-dimensional, full-face reconstruction: a technical evaluation. Am J Orthod Dentofac Orthop. 2010;138(1):84–8.CrossRefGoogle Scholar
  39. 39.
    Xia J, Li Y, Cai D, et al. Direct resin composite restoration of maxillary central incisors using a 3D-printed template: two clinical cases. BMC Oral Health. 2018;18:158.PubMedPubMedCentralCrossRefGoogle Scholar
  40. 40.
    Maass H, Chantier BB, Cakmak HK, et al. Fundamentals of force feedback and application to a surgery simulator. Comput Aid Surg. 2003;8:283–91.CrossRefGoogle Scholar
  41. 41.
    Cosman PH, Cregan PC, Martin CJ, et al. Virtual reality simulators: current status in acquisition and assessment of surgical skills. ANZ J Surg. 2002;72:30–4.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Shah P, Chong BS. 3D imaging, 3D printing and 3D virtual planning in endodontics. Clin Oral Investig. 2018;22(2):641–54.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Suebnukarn S, Haddawy P, Rhienmora P, Gajananan K. Haptic virtual reality for skill acquisition in endodontics. J Endod. 2010;36(1):53–5.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2021

Authors and Affiliations

  • Niraj Kinariwala
    • 1
    Email author
  • Lakshman Samaranayake
    • 2
  • Gunpreet Oberoi
    • 3
  • Hermann Agis
    • 3
  1. 1.Karnavati School of DentistryKarnavati UniversityGandhinagarIndia
  2. 2.Faculty of DentistryUniversity of Hong KongHong KongChina
  3. 3.Department of Conservative Dentistry and Periodontology, University Clinic of DentistryMedical University of ViennaViennaAustria

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