Synthesis, Spectroscopy and Structures of Complexes of PD(II) with 4N-Substituted Derivatives of 2-Acetylpyridine Thiosemicarbazone
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The reactions of 2-acetylpyridine thiosemicarbazone (HAc4DH), 4N-phenyl-2- acetylpyridine thiosemicarbazone (HAc4Ph), and 4N-dimethyl-2-acetyl pyridine thiosemicarbazone (HAc4DM) with palladium(II) were studied. The ligands and the palladium(II) complexes have been characterized by spectroscopic, structural and electrochemical techniques. Their effect on DNA synthesis of P388 and LI210 cell cultures is also reported.
KeywordsPalladium complexes 4N-substituted thiosemicarbazones antitumour activity
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