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Sequential Oligopeptide Carriers (SOCn) for Producing Potent Antigens and Effective Immunogens

  • C. Sakarellos
  • V. Tsikaris
  • M. Sakarellos-Daitsiotis
Chapter
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Part of the NATO ASI Series book series (ASEN2, volume 26)

Abstract

A new class of Sequential Oligopeptide Carriers (SOCn), namely (Lys-Aib-Gly)n (n=2–7), for anchoring antigenic/immunogenic peptides is presented. The aim of this construction was to model artificial carriers with predetermined conformation, so that the attached peptides would not interact to each other or with the carrier, and would thus retain their original active conformation. The NMR study and the molecular dynamics calculations confirmed that the SOCn adopt rigid helicoid structure comparable to a canonical 310-helix, with a somewhat curved axis. The peptides linked to the SOCn retain their original structural profile, as it was also demonstrated by the NMR study. It is concluded that the SOCn impose a favourable disposition of the anchored peptides for generating potent antigens and effective immunogens.

Keywords

Amide Proton Potent Antigen Multiple Antigenic Peptide Curve Axis Preparative High Performance Liquid Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1997

Authors and Affiliations

  • C. Sakarellos
    • 1
  • V. Tsikaris
    • 1
  • M. Sakarellos-Daitsiotis
    • 1
  1. 1.Department of ChemistryUniversity of IoanninaIoanninaGreece

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