Approach to Lymph Node Cytology
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Lymph nodes are often a microcosm of diseases in the rest of the body, reflecting not only local, but regional and sometimes systemic disease. This chapter provides a framework of the role and limitations of lymph node FNAs. A sequential, pattern-based approach to lymph node cytology is outlined, together with a summary of the types of ancillary tests available, with an emphasis on one’s individual laboratory practice setting.
Lastly, specific danger zones in terms of potential false positives, negatives and mimics are also discussed, along with clues and practical tips.
- 2.Alsharif M, Andrade RS, Groth SS, Stelow EB, Pambuccian SE. Endobronchial ultrasound–guided transbronchial fine-needle aspiration: the University of Minnesota experience, with emphasis on usefulness, adequacy assessment, and diagnostic difficulties. Am J Clin Pathol. 2008;130(3):434–43.PubMedCrossRefGoogle Scholar
- 3.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (Eds). WHO Classification of Tumours of Haematopoeitic and Lymphoid Tissues (Revised 4th edition). IARC: Lyon 2017.Google Scholar
- 11.Mills SE, editor. Histology for pathologists: includes online access for fully searchable text and image bank. 4th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health; 2012. 1331 p.Google Scholar
- 22.Kishimoto K, Kitamura T, Fujita K, Tate G, Mitsuya T. Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: cytologic features of fine-needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chromosomal translocation. Diagn Cytopathol. 2006;34(1):11–7.PubMedCrossRefGoogle Scholar