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Introduction to Cancer Stem Cells

  • Anisur Rahman Khuda-Bukhsh
  • Asmita Samadder
  • Santu Kumar Saha
Chapter
  • 76 Downloads

Abstract

Cancer is a persistent public health-care issue of modern life that poses a global challenge. It comprises several diseases that basically involve abnormal cell growth and have a potential to invade or metastasize to other distant organ systems, spreading the disease to other part(s) of the body. Development of resistance to conventional therapies and disease recurrence are some common phenomena encountered in almost all types of cancer. Understanding “hallmarks of cancer” and “tumor microenvironment” is therefore important for development of successful therapy for cancer. Numerous drugs have been designed and tested for their anticancer efficacy over decades to find out a complete cure for this lethal disease, but without desirable success so far. The concept and role of “stem cell” therapy in oncology research have drawn considerable interest in recent years. Thus, emphasis has been given on proper identification and characterization of the “cancer stem cells” and “other stem cells” for elucidation of the signaling cascades involved in the process of cancer limitation and progression (and resurgence). In the introductory part of this book, an attempt has been made to provide an overall idea on different aspects of cancer stem cells, optimization of rate and type of cell growth, and their associative cure strategy by adopting a well-defined scientific perspective.

Keywords

Cancer Stem cell types Cancer stem cell Stem cell therapy Targeted therapy Therapy resistance 

Abbreviations

AML

Acute myeloid leukemia

CSC

Cancer stem cell (CSC)

DNA

Deoxyribonucleic acid

EMT

Epithelial to mesenchymal transition

EPC

Endothelial progenitor cell

FACS

Fluorescence-activated cell sorter

HSC

Hematopoietic stem cell

HSCT

Hematopoietic stem cell transplant

MET

Mesenchymal-epithelial transition

MSC

Mesenchymal stem cell

NSC

Neural stem cell

ROS

Reactive oxygen species

SSC

Somatic stem cell

TSG

Tumor suppressor gene

HSCTs

Hematopoietic stem cell transplants

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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Anisur Rahman Khuda-Bukhsh
    • 1
  • Asmita Samadder
    • 2
  • Santu Kumar Saha
    • 3
  1. 1.Emeritus Professor of University Grants Commission at University of KalyaniKalyaniIndia
  2. 2.Cytogenetics and Molecular Biology Laboratory, Department of ZoologyUniversity of KalyaniKalyaniIndia
  3. 3.Newcastle University Centre for CancerFaculty of Medical School Newcastle upon TyneUK

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