Lanthanide-Labeled DNA

  • Paul R. Selvin
Part of the Topics in Fluorescence Spectroscopy book series (TIFS, volume 7)


Lanthanides, as alternative probes to conventional fluorophores, can lead to enhanced sensitivity in applications where autofluorescence is a problem. Multiple labeling with lanthanide chelates have been shown to be an effective method for further increases in sensitivity. These probes, being nonisotopic, avoid the many practical problems associated with radioactive probes. Lanthanide probes are particularly advantageous in resonance energy transfer, whether for measuring distances in biocomplexes or when used to generate new lifetime tailored dyes.


Fluorescence Resonance Energy Transfer Resonance Energy Transfer Tyramide Signal Amplification Fluorescence Energy Transfer Lanthanide Chelate 
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© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Paul R. Selvin
    • 1
  1. 1.Physics Department and Biophysics CenterUniversity of IllinoisUrbana

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