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PNAs as Novel Cancer Therapeutics

  • Luca Mologni
  • Carlo Gambacorti-Passerini
Chapter
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Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Peptide nucleic acid (PNA) is a hybrid compound with nucleoside bases linked to a peptide-like amide backbone. PNA is capable of sequence-specific base pairing and forms highly stable double and triple helices with natural nucleic acids (DNA, RNA). PNA forms stable hydrogen bonds and is resistant to degradation by nudeases and proteases. Because of these physicochemical properties, PNA has attracted great attention, since its first description in 1991, as a potential gene-specific drug and a versatile molecular biology tool. More and more laboratories are working with PNA and the number of applications in which PNA proves useful continues to increase.

In this chapter, we describe aspects of the biochemistry of peptide nucleic acids and their use as a molecular biology reagent, and then focus on the antisense and anti-gene activity of PNA, with special reference to studies of medical interest, in particular in the PML/RARα and the bcl-2 systems.

Keywords

Peptide Nucleic Acid Cancer Therapeutics Antisense ODNs Galanin Receptor Peptide Nucleic Acid Probe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Eurekah.com and Kluwer Academic / Plenum Publishers 2006

Authors and Affiliations

  • Luca Mologni
    • 1
    • 2
  • Carlo Gambacorti-Passerini
    • 3
  1. 1.Department of Clinical MedicineUniversity of Milano-BicoccaMonzaItaly
  2. 2.Department of Experimental OncologyNational Cancer InstituteMilanItaly
  3. 3.Oncogenic Fusion Proteins Unit, Department of Experimental OncologyNational Cancer InstituteMilanItaly

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