Protective effect on nephrotoxicity

  • Choung Se Young 

4.6.3. Conclusion

The objective of this study was to assess the effect and the mechanism of action of prokidin (a chromone compound found naturally as one of the ingredients of aloe) in terms of reducing cisplatin nephrotoxicity. The results indicated that prokidin was by far the most effective suppressant of cisplatin nephrotoxicity. The optimal cisplatin dosage was found to be 3 doses of 60mg/kg each and the optimal timing to be 72, 48 and 24 hours before cisplatin administration. The absence of any deleterious influence on cisplatin’s anti-cancer effect was also confirmed. The mechanism of nephrotoxicity suppression was by way of its effect on the neutrophil function of the renal blood. It stimulated the neutrophils to discharge oxygen radicals, thus preventing them from damaging organs. Based on these findings, we are of the view that prokidin has potential as a drug for reducing cisplatin-induced nephrotoxicity. However, successful efficacy trials with human subjects are required before it can be considered for clinical use.


Coculture System Thrombotic Microangiopathy Distal Convoluted Tubule Proximal Convoluted Tubule Effective Suppressant 
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© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Choung Se Young 
    • 1
  1. 1.College of PharmacyKyung Hee UniversitySeoulKorea

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