A Computational Model of Degeneracy in a Lymph Node

  • Paul S. Andrews
  • Jon Timmis
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4163)


This paper highlights degeneracy as being an important property in both the immune system and biology in general. From this, degeneracy is chosen as a candidate to inspire artificial immune systems. As a first step in exploiting the power of degeneracy, we follow the conceptual framework approach and build an abstract computational model in order to understand the properties of degenerate detectors free of any application bias. The model we build is based on the activation of TH cell in the lymph node, as lymph nodes are the sites in the body where the adaptive immune response to foreign antigen in the lymph are activated. The model contains APC, antigen and TH cell agents that move and interact in a 2-dimensional cellular space. The TH cell agent receptors are assumed to be degenerate and their response to different antigen agents is measured. Initial observations and results of our model are presented and highlight some of the possibilities of degenerate detector recognition.


Adaptive Immune Response Cell Agent Foreign Antigen Chemical Space Cellular Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Andrews, P.S., Timmis, J.: Inspiration for the Next Generation of Artificial Immune Systems. In: Jacob, C., Pilat, M.L., Bentley, P.J., Timmis, J.I. (eds.) ICARIS 2005. LNCS, vol. 3627, pp. 126–138. Springer, Heidelberg (2005)CrossRefGoogle Scholar
  2. 2.
    Hart, E., Timmis, J.: Application Areas of AIS: The Past, The Present and The Future. In: Jacob, C., Pilat, M.L., Bentley, P.J., Timmis, J.I. (eds.) ICARIS 2005. LNCS, vol. 3627, pp. 483–497. Springer, Heidelberg (2005)CrossRefGoogle Scholar
  3. 3.
    Cohen, I.R.: Discrimination and dialogue in the immune system. Seminars in Immunology 12, 215–219 (2000)CrossRefGoogle Scholar
  4. 4.
    Cohen, I.R.: Tending Adam’s Garden: Evolving the Cognitive Immune Self. Elsevier Academic Press, Amsterdam (2000)Google Scholar
  5. 5.
    Cohen, I.R.: The creation of immune specificity. In: Segal, L.A., Cohen, I.R. (eds.) Design Principles for Immune Systems and Other Distributed Autonomous Systems, pp. 151–159. Oxford University Press, Oxford (2001)Google Scholar
  6. 6.
    Cohen, I.R., Hershberg, U., Solomon, S.: Antigen-receptor degeneracy and immunological paradigms. Molecular Immunology 40, 993–996 (2004)CrossRefGoogle Scholar
  7. 7.
    Stepney, S., Smith, R., Timmis, J., Tyrrell, A., Neal, M., Hone, A.: Conceptual frameworks for artificial immune systems. International Journal of Unconventional Computing 1 (2005)Google Scholar
  8. 8.
    Edelman, G.M., Gally, J.A.: Degeneracy and complexity in biological systems. Proceedings of the National Academy of Science (PNAS) 98, 13763–13768 (2001)CrossRefGoogle Scholar
  9. 9.
    Parnes, O.: From interception to incorporation: Degeneracy and promiscuous recognition as precursors of a paradigm shift in immunology. Molecular Immunology 40, 985–991 (2004)CrossRefGoogle Scholar
  10. 10.
    Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge (1959)Google Scholar
  11. 11.
    Sercarz, E.E., Maverakis, E.: Recognition and function in a degenerate immune system. Molecular Immunology 40, 1003–1008 (2004)CrossRefGoogle Scholar
  12. 12.
    Tieri, P., Castellani, G.C., Remondini, D., Valensin, S., Loroni, J., Salvioli, S., Franceschi, C.: Capturing degeneracy of the immune system. In: Flower, D., Timmis, J. (eds.) Silico Immunology. Springer, Heidelberg (to appear, 2007)Google Scholar
  13. 13.
    Abbas, A.K., Lichtman, A.H.: Cellular and Molecular Immunology, 5th edn. Saunders, Philadelphia (2003)Google Scholar
  14. 14.
    Goldsby, R.A., Kindt, T.J., Osborne, B.A., Kuby, J.: Immunology, 5th edn. W. H. Freeman and Company, New York (2003)Google Scholar
  15. 15.
    Janeway, C.A., Travers, P., Walport, M., Shlomchik, M.: Immunobiology, 5th edn. Garland Publishing (2001)Google Scholar
  16. 16.
    Anderton, S.M., Wraith, D.C.: Selection and fine-tuning of the autoimmune t-cell repertoire. Nature Reviews Immunology 2, 487–498 (2002)CrossRefGoogle Scholar
  17. 17.
    Maree, A.F.M., Panfilov, A.V., Hogeweg, P.: Migration and thermotaxis of Dictyostelium discoideum slugs, a model study. Journal of Theoretical Biology 199, 297–309 (1999)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Paul S. Andrews
    • 1
  • Jon Timmis
    • 1
    • 2
  1. 1.Department of Computer ScienceUniversity of YorkUK
  2. 2.Department of ElectronicsUniversity of YorkUK

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