Modelling the Control of an Immune Response Through Cytokine Signalling

  • Thiago Guzella
  • Tomaz Mota-Santos
  • Joaquim Uchôa
  • Walmir Caminhas
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 4163)


This paper presents the computer aided simulation of a model for the control of an immune response. This model has been developed to investigate the proposed hypothesis that the same cytokine that amplifies an initiated response can eventually lead to its downregulation, if it can act on more than one cell type. The simulation environment is composed of effector cells and regulatory cells; the former, when activated, initiate an immune response, while the latter are responsible for controlling the magnitude of the response. The signalling that coordinates this process is modelled using stimulation and regulation cytokines. Simulation results obtained, in accordance with the motivating idea, are presented and discussed.


Regulatory Cell Cytokine Secretion Cytokine Signalling Cytokine Absorption Regulatory Cytokine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Thiago Guzella
    • 1
  • Tomaz Mota-Santos
    • 2
  • Joaquim Uchôa
    • 3
  • Walmir Caminhas
    • 1
  1. 1.Electrical Engineering Dept.Federal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Biochemistry and Immunology Dept.Federal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Computer Science Dept.Federal University of LavrasLavrasBrazil

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