Imaging the Viscoelastic Properties of Tissue

  • Mostafa Fatemi
  • James F. Greenleaf
Part of the Topics in Applied Physics book series (TAP, volume 84)


Elasticity and viscosity of soft tissues are often related to pathology. These parameters, along with other mechanical parameters, determine the dynamic response of tissue to a force. Tissue mechanical response, therefore, may be used for diagnosis. Measuring and imaging of the mechanical properties of tissues is the aim of a class of techniques generally called elasticity imaging or elastography. The general approach is to measure tissue motion caused by a force or displacement and use it to reconstruct the elastic parameters of the tissue. The excitation stress can be either static or dynamic (vibration). Dynamic excitation is of particular interest because it provides more comprehensive information about tissue properties in a spectrum of frequencies. In one approach an external stress field must pass through the superficial portion of the object before reaching the region of interest within the interior. An alternative strategy is to apply a localized stress directly in the region of interest. One way to accomplish this task is to use the radiation force of ultrasound. This approach offers several benefits, including: (a) safety—acoustic energy is a noninvasive means of exerting force; (b) adaptability — existing ultrasound technology and devices can be readily modified for this purpose; (c) remoteness — radiation force can be generated remotely inside tissue without disturbing its superficial layers; (d) localization — the radiation stress field can be highly localized, thus allowing for precise positioning of the excitation point; and (e) a wide frequency spectrum. Several methods have been developed for tissue probing using the dynamic radiation force of ultrasound, including: (a) transient methods which are based on impulsive radiation force; (b) shear-wave methods which are based on generation of shear-waves; and (c) vibro-acoustography, recently developed by the authors, where a localized oscillating radiation force is applied to the tissue and the acoustic response of the tissue is detected by a hydrophone. Here, we focus on vibro-acoustography and present a detailed description of the theory and the experimental results. We conclude with the capabilities and limitations of these radiation-force methods.


Acoustic Emission Viscoelastic Property Radiation Pressure Radiation Force Magnetic Resonance Elastography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    L. Gao, K. J. Parker, R. M. Lerner, S. F. Levinson, Imaging of the elastic properties of tissue-a review, Ultrasound Med. Biol. 22, 959–977 (1996)CrossRefGoogle Scholar
  2. 2.
    R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, R. L. Ehman, Magnetic resonance elastography by direct visualization of propagating acoustic strain waves, Science 269, 1854–1857 (1995)CrossRefADSGoogle Scholar
  3. 3.
    B. T. Chu, R. E. Apfel, Acoustic radiation pressure produced by a beam of sound. J. Acoust. Soc. Am. 72, 1673–1687 (1982)CrossRefADSGoogle Scholar
  4. 4.
    T. Sugimoto, S. Ueha, K. Itoh, Tissue hardness measurement using the radiation force of focused ultrasound, IEEE Ultrasonics Symp. Proc. 3, 1377–1380 (1990)CrossRefGoogle Scholar
  5. 5.
    V. Andreev, V. Dmitriev, O. V. Rudenko, A. Sarvazyan, A remote generation of shear-wave in soft tissue by pulsed radiation pressure, J. Acoust. Soc. Am. 102, 3155 (1997)CrossRefADSGoogle Scholar
  6. 6.
    A. P. Sarvazyan, O. V. Rudenko, S. D. Swanson, J. B. Fowlkes, S. Y. Emelianov, Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics, Ultrasound Med. Biol. 24, 1419–1435 (1998)CrossRefGoogle Scholar
  7. 7.
    W. F. Walker, Internal deformation of a uniform elastic solid by acoustic radiation, J. Acoust. Soc. Am. 105, 2508–2518 (1999)CrossRefADSGoogle Scholar
  8. 8.
    M. Fatemi, J. F. Greenleaf, Ultrasound-stimulated vibro-acoustic spectrography, Science 280, 82–85 (1998)CrossRefADSGoogle Scholar
  9. 9.
    M. Fatemi, J. F. Greenleaf, Vibro-acoustography: An imaging modality based on ultrasound-stimulated acoustic emission, Proc. Natl. Acad. Sci. USA 96, 6603–6608 (1999)CrossRefADSGoogle Scholar
  10. 10.
    Lord Raleigh, Philos. Mag. 3, 338–346 (1902); see also: Lord Raleigh, Philos. Mag. 10, 364–374 (1905)Google Scholar
  11. 11.
    R. T. Beyer, Radiation pressure-the history of a mislabeled tensor, J. Acoust. Soc. Am. 63, 1025–1030 (1978)CrossRefADSGoogle Scholar
  12. 12.
    O. V. Rudenko, A. P. Sarvazian, S. Y. Emelionov, Acoustic radiation force and streaming induced by focused nonlinear ultrasound in a dissipative medium, J. Acoust. Soc. Am. 99, 1–8 (1996)Google Scholar
  13. 13.
    Jiang Z-Y, J. F. Greenleaf, Acoustic radiation pressure in a three-dimensional lossy medium, J. Acoust. Soc. Am. 100, 741–747 (1996)CrossRefADSGoogle Scholar
  14. 14.
    P. J. Westervelt, The theory of steady force caused by sound waves, J. Acoust. Soc. Am. 23, 312–315 (1951)CrossRefADSMathSciNetGoogle Scholar
  15. 15.
    S. A. Goss, R. L. Johnston, F. Dunn, Comprehensive compilation of empirical ultrasonic properties of mammalian tissues, J. Acoust. Soc. Am. 64, 423–457 (1978)CrossRefADSGoogle Scholar
  16. 16.
    L. A. Frizzell, E. L. Carstensen, Shear properties of mammalian tissues at low megahertz frequencies, J. Acoust. Soc. Am. 60, 1409–1411 (1976)CrossRefADSGoogle Scholar
  17. 17.
    P. M. Morse, K. U. Ingard (Eds.) Theoretical Acoustics (McGraw-Hill, New York 1968)Google Scholar
  18. 18.
    M. Fatemi, J. F. Greenleaf, Application of radiation force in noncontact measurement of the elastic parameters, Ultrasonic Imaging 21, 147–154 (1999)Google Scholar
  19. 19.
    M. Fatemi, J. F. Greenleaf, Remote measurement of shear viscosity with ultrasound-stimulated vibro-acoustic spectrography, Acta Phys. Sin. 8, S27–S32 (1999)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2002

Authors and Affiliations

  • Mostafa Fatemi
    • 1
  • James F. Greenleaf
    • 1
  1. 1.Department of Physiology and BiophysicsMayo Clinic and Mayo FoundationRochesterUSA

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