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Plant Cells pp 103-125 | Cite as

Genetic Modification of Plant Secondary Metabolite Pathways Using Transcriptional Regulators

  • Johan Memelink
  • Jan W. Kijne
  • Robert van der Heijden
  • Rob Verpoorte
Chapter
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 72)

Abstract

Plant secondary metabolism is the source of many natural products with diverse applications, including pharmaceuticals, food colors, dyes and fragrances. Functions in plants include attraction of pollinating insects and protection against pests and pathogens. An important regulatory step in secondary metabolism is transcription of the biosynthetic genes. The aim of this chapter is to discuss results and opportunities concerning modification of secondary metabolism using transcriptional regulators. The transcriptional regulation of two well-studied secondary pathways, the phenylpropanoid pathway and its flavonoid branch, and the terpenoid indole alkaloid biosynthetic pathway, are reviewed. Some examples of successful engineering of these pathways via transcriptional regulators are discussed.

Keywords

Anthocyanins AP2-domain Jasmonate Terpenoid indole alkaloids Transcription factor 

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References

  1. 1.
    Verpoorte R, van der Heijden R, Memelink J (1998) Plant biotechnology and the production of alkaloids: prospects of metabolic engineering. In: Cordell GA (ed) The alka-loids, vol 50. Academic Press, San Diego, p 453Google Scholar
  2. 2.
    Verpoorte R, van der Heijden R, ten Hoopen HJG, Memelink J (1999) Biotechnol Lett 21:467CrossRefGoogle Scholar
  3. 3.
    Verpoorte R, van der Heijden R, Memelink J (2000) General strategies. In: Verpoorte R, Alfermann AW (eds) Metabolic engineering of plant secondary metabolism. Kluwer, Dordrecht, p 31Google Scholar
  4. 4.
    Nikolov DB, Burley SK (1997) Proc Natl Acad Sci USA 94:15CrossRefGoogle Scholar
  5. 5.
    Kaiser K, Meisterernst M (1996) Trends Biochem Sci 21:342CrossRefGoogle Scholar
  6. 6.
    Molkentin JD, Olson EN (1996) Proc Natl Acad Sci USA 93:9366CrossRefGoogle Scholar
  7. 7.
    Lawrence PA, Morata G (1994) Cell 78:181CrossRefGoogle Scholar
  8. 8.
    Graba Y, Aragnol D, Pradel J (1997) BioEssays 19:379CrossRefGoogle Scholar
  9. 9.
    Jaglo-Ottosen KR, Gilmour SJ, Zarka DG, Schabenberger O, Thomashow MF (1998) Science 280:104CrossRefGoogle Scholar
  10. 10.
    Holton TA, Cornish EC (1995) Plant Cell 7:1071CrossRefGoogle Scholar
  11. 11.
    Roth BA, Goff SA, Klein TM, Fromm ME (1991) Plant Cell 3:317CrossRefGoogle Scholar
  12. 12.
    Moyano E, Martinez-Garcia JF, Martin C (1996) Plant Cell 8:1519CrossRefGoogle Scholar
  13. 13.
    Sainz MB, Grotewold E, Chandler VL (1997) Plant Cell 9:611CrossRefGoogle Scholar
  14. 14.
    Martin C, Paz-Ares J (1997) Trends Genet 13:67–73CrossRefGoogle Scholar
  15. 15.
    Jin H, Martin C (1999) Plant Mol Biol 41:577CrossRefGoogle Scholar
  16. 16.
    de Pater S, Pham K, Memelink J, Kijne J (1997) Plant Mol Biol 34:169CrossRefGoogle Scholar
  17. 17.
    Martínez-García JF, Huq E, Quail PH (2000) Science 288:859CrossRefGoogle Scholar
  18. 18.
    Menkens AE, Schindler U, Cashmore AR (1995) Trends Biochem Sci 20:506CrossRefGoogle Scholar
  19. 19.
    Goff SA, Cone KC, Chandler VL (1992) Genes Dev 6:864CrossRefGoogle Scholar
  20. 20.
    Mol J, Grotewold E, Koes R (1998) Trends Plant Sci 3:212CrossRefGoogle Scholar
  21. 21.
    Lloyd AM, Walbot V, Davis RW (1992) Science 258:1773CrossRefGoogle Scholar
  22. 22.
    Bradley JM, Davies KM, Deroles SC, Bloor SJ, Lewis DH (1998) Plant J 13:381CrossRefGoogle Scholar
  23. 23.
    Ludwig SR, Wessler SR (1990) Cell 62:849CrossRefGoogle Scholar
  24. 24.
    de Vetten N, Quattrocchio F, Mol J, Koes R (1997) 11:1422Google Scholar
  25. 25.
    Walker AR, Davison PA, Bolognesi-Winfield AC, James CM, Srinivasan N, Blundell TL, Esch JJ, Marks MD, Gray JC (1999) Plant Cell 11:1337CrossRefGoogle Scholar
  26. 26.
    McCarthy DR, Carson CB, Stinard PS, Robertson DS (1989) Plant Cell 1:523CrossRefGoogle Scholar
  27. 27.
    Hattori T, Vasil V, Rosenkrans L, Hannah LC, McCarty DR, Vasil IK (1992) Genes Dev 6:609CrossRefGoogle Scholar
  28. 28.
    Suzuki M, Kao CY, McCarty DR (1997) Plant Cell 9:799CrossRefGoogle Scholar
  29. 29.
    Blackwood EM, Eisenman RN (1991) Science 251:1211CrossRefGoogle Scholar
  30. 30.
    Gu W, Bhatia K, Magrath IT, Dang CV, Dalla-Favera R (1994) Science 264:251CrossRefGoogle Scholar
  31. 31.
    Hunter T, Karin M (1992) Cell 70:375CrossRefGoogle Scholar
  32. 32.
    Lüscher B, Cristenson E, Litchfield DW, Krebs EG, Eisenman RN (1990) Nature 344:517CrossRefGoogle Scholar
  33. 33.
    Myrset AH, Bostad A, Jamin N, Lirsac PN, Toma F, Gabrielsen OS (1993) EMBO J 12:4625Google Scholar
  34. 34.
    Oelgeschläger M, Janknecht R, Krieg J, Schreek S, Luescher B (1996) EMBO J 15:2771Google Scholar
  35. 35.
    Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei-Ishii C, Takahashi T, Ishii S (1996) Genes Dev 10:528CrossRefGoogle Scholar
  36. 36.
    Dixon RA, Paiva NL (1995) Plant Cell 7:1085CrossRefGoogle Scholar
  37. 37.
    Schulze-Lefert P, Dangl JL, Becker-André M, Hahlbrock K, Schulz W (1989) EMBO J 8:651Google Scholar
  38. 38.
    Dron M, Clouse SD, Dixon RA, Lawton MA, Lamb CJ (1988) Proc Natl Acad Sci USA 85:6738CrossRefGoogle Scholar
  39. 39.
    Lois R, Dietrich A, Hahlbrock K, Schulz W (1989) EMBO J 8:1641Google Scholar
  40. 40.
    Becker-André M, Schulze-Lefert P, Hahlbrock K (1991) J Biol Chem 266:8551Google Scholar
  41. 41.
    Weisshaar B, Armstrong GA, Block A, da Costa e Silva O, Hahlbrock K (1991) EMBO J 10:1777Google Scholar
  42. 42.
    Hartmann U, Valentine WJ, Christie JM, Hays J, Jenkins GI, Weisshaar B (1998) Plant Mol Biol 36:741CrossRefGoogle Scholar
  43. 43.
    Ang L-H, Chattopadhyay S, Wei N, Oyama K, Batschauer A, Deng XW (1998) Mol Cell 1:213CrossRefGoogle Scholar
  44. 44.
    Sablowski RWM, Moyano E, Culianez-Marcia FA, Schuch W, Martin C, Bevan M (1994) EMBOJ 13:128Google Scholar
  45. 45.
    Feldbrügge M, Sprenger M, Hahlbrock K, Weisshaar B (1997) Plant J 11:1079CrossRefGoogle Scholar
  46. 46.
    Dröge-Laser W, Kaiser A, Lindsay WP, Halkier BA, Loake GJ, Doerner P, Dixon RA, Lamb C (1997) EMBOJ 16:726CrossRefGoogle Scholar
  47. 47.
    da Costa e Silva O, Klein L, Schmelzer E, Trezzini GF, Hahlbrock K (1993) Plant J 4:125CrossRefGoogle Scholar
  48. 48.
    van der Fits L, Zhang H, Menke FLH, Deneka M, Memelink J (2000) Plant Mol Biol 44:675CrossRefGoogle Scholar
  49. 49.
    Mooney M, Desnos T, Harrison K, Jones J, Carpenter R, Coen E (1995) Plant J 7:333CrossRefGoogle Scholar
  50. 50.
    Grotewold E, Chamberlin M, Snook M, Siame B, Butler L, Swenson J, Maddock S, St. Clair G, Bowen B (1998) Plant Cell 10:721CrossRefGoogle Scholar
  51. 51.
    Vick BA, Zimmerman DC (1984) Plant Physiol 75:458CrossRefGoogle Scholar
  52. 52.
    Mueller MJ (1997) Physiol Plant 100:653CrossRefGoogle Scholar
  53. 53.
    Farmer EE, Ryan CA (1992) Plant Cell 4:129CrossRefGoogle Scholar
  54. 54.
    Gundlach H, Müller MJ, Kutchan TM, Zenk MH (1992) Proc Natl Acad Sci USA 89:2389CrossRefGoogle Scholar
  55. 55.
    Mueller MJ, Brodschelm W, Spannagl E, Zenk MH (1993) Proc Natl Acad Sci USA 90:7490CrossRefGoogle Scholar
  56. 56.
    Ellard-Ivey M, Douglas CJ (1996) Plant Physiol 112:183Google Scholar
  57. 57.
    Nojiri H, Sugimori M, Yamane H, Nishimura Y, Yamada A, Shibuya N, Kodama O, Murofushi N, Omori T (1996) Plant Physiol 110:387Google Scholar
  58. 58.
    Blechert S, Brodschelm W, Hölder W, Kammerer L, Kutchan TM, Mueller MJ, Xia Z-Q, Zenk MH (1995) Proc Natl Acad Sci USA 92:4099CrossRefGoogle Scholar
  59. 59.
    Parchmann S, Gundlach H, Mueller MJ (1997) Plant Physiol 115:1057CrossRefGoogle Scholar
  60. 60.
    Blechert S, Bockelmann C, Füßlein M, v Schrader T, Stelmach B, Niesel U, Weiler EW (1999) Planta 207:470CrossRefGoogle Scholar
  61. 61.
    Seo S, Okamoto M, Seto H, Ishizuka K, Sano H, Ohashi Y (1995) Science 270:1988CrossRefGoogle Scholar
  62. 62.
    Seo S, Sano H, Ohashi Y (1999) Plant Cell 11:289CrossRefGoogle Scholar
  63. 63.
    Stratmann JW, Ryan CA (1997) Proc Natl Acad Sci USA 94:11085CrossRefGoogle Scholar
  64. 64.
    Menke FLH, Parchmann S, Mueller MJ, Kijne JW, Memelink J (1999) Plant Physiol 119:1289CrossRefGoogle Scholar
  65. 65.
    Aerts RJ, Snoeijer W, Aerts-Teerlink O, van der Meijden E, Verpoorte R (1991) Phytochemistry 30:3571CrossRefGoogle Scholar
  66. 66.
    Aerts RJ, Stoker A, Beishuizen M, Jaarsma I, van de Heuvel M, van der Meijden E, Verpoorte R (1992) J Chem Ecol 18:1955CrossRefGoogle Scholar
  67. 67.
    Luijendijk TJC (1995) PhD thesis, Leiden University, The NetherlandsGoogle Scholar
  68. 68.
    Contin A, van der Heijden R, Lefeber AWM, Verpoorte R (1998) FEBS Lett 434:413CrossRefGoogle Scholar
  69. 69.
    Rohmer M, Knani M, Simonin P, Sutter B, Sahm H (1993) Biochem J 295:517Google Scholar
  70. 70.
    Meijer AH, Verpoorte R, Hoge JHC (1993) J Plant Res 3:145Google Scholar
  71. 71.
    De Luca V, St-Pierre B (2000) Trends Plant Sci 5:168CrossRefGoogle Scholar
  72. 72.
    Moreno PRH, van der Heijden R, Verpoorte R (1995) Plant Cell Tiss Org Cult 42:1CrossRefGoogle Scholar
  73. 73.
    Aerts RJ, Gisi D, De Carolis E, De Luca V, Baumann TW (1994) Plant J 5:635CrossRefGoogle Scholar
  74. 74.
    Gantet P, Imbault N, Thiersault M, Doireau P (1998) Plant Cell Physiol 39:220Google Scholar
  75. 75.
    Ouwerkerk PBF, Hallard D, Verpoorte R, Memelink J (1999) Plant Mol Biol 41:491CrossRefGoogle Scholar
  76. 76.
    Kutchan TM, Hampp N, Lottspeich F, Beyreuther K, Zenk MH (1988) FEBS Lett 237:40CrossRefGoogle Scholar
  77. 77.
    McKnight TD, Roessner CA, Devagupta R, Scott AI, Nessler CL (1990) Nucl Acids Res 18:4939CrossRefGoogle Scholar
  78. 78.
    Pasquali G, Goddijn OJM, de Waal A, Verpoorte R, Schilperoort RA, Hoge JHC, Memelink J (1992) Plant Mol Biol 18:1121CrossRefGoogle Scholar
  79. 79.
    Bracher D, Kutchan TM (1992) Arch Bioch Biophys 294:717CrossRefGoogle Scholar
  80. 80.
    Pasquali G, Erven ASW, Ouwerkerk PBF, Menke FLH, Memelink J (1999) Plant Mol Biol 39:1299CrossRefGoogle Scholar
  81. 81.
    De Luca V, Marineau C, Brisson N (1989) Proc Natl Acad Sci USA 86:2582CrossRefGoogle Scholar
  82. 82.
    Goddijn OJM, Lohman FP, de Kam RJ, Schilperoort RA, Hoge JHC (1994) Mol Gen Genet 242:217CrossRefGoogle Scholar
  83. 83.
    Goddijn OJM, de Kam RJ, Zanetti A, Schilperoort RA, Hoge JHC (1992) Plant Mol Biol 18:1113CrossRefGoogle Scholar
  84. 84.
    Roewer IA, Cloutier C, Nessler CL, De Luca V (1992) Plant Cell Rep 11:86CrossRefGoogle Scholar
  85. 85.
    Menke FLH (1999) PhD thesis, Leiden University, The NetherlandsGoogle Scholar
  86. 86.
    López-Meyer M, Nessler CL (1997) Plant J 11:1167CrossRefGoogle Scholar
  87. 87.
    Collu G (1999) PhD thesis, Leiden University, The NetherlandsGoogle Scholar
  88. 88.
    Meijer AH, Lopes Cardoso MI, Voskuilen JT, de Waal A, Verpoorte R, Hoge JHC (1993) Plant J 4:47CrossRefGoogle Scholar
  89. 89.
    Geerlings A, Martinez-Lozano Ibanez M, Memelink J, van der Heijden R, Verpoorte R (2000) J Biol Chem 275:3051CrossRefGoogle Scholar
  90. 90.
    Lopes Cardoso MI, Meijer AH, Rueb S, Queiroz Machado J, Memelink J, Hoge JHC (1997) Mol Gen Genet 256:674Google Scholar
  91. 91.
    van der Fits L, Memelink J (2000) Science 289:295CrossRefGoogle Scholar
  92. 92.
    Schröder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schröder J (1999) FEBS Lett 458:97CrossRefGoogle Scholar
  93. 93.
    St-Pierre B, Laflamme P, Alarco A-M, De Luca V (1998) Plant J 14:703CrossRefGoogle Scholar
  94. 94.
    Vazquez-Flota F, De Carolis E, Alarco A-M, De Luca V (1997) Plant Mol Biol 34:935CrossRefGoogle Scholar
  95. 95.
    Menke FLH, Champion A, Kijne JW, Memelink J (1999) EMBO J 18:4455CrossRefGoogle Scholar
  96. 96.
    Riechmann JL, Meyerowitz EM (1998) Biol Chem 379:633CrossRefGoogle Scholar
  97. 97.
    Fujimoto SY, Ohta M, Usui A, Shinshi H, Ohme-Takagi M (2000) Plant Cell 12:393CrossRefGoogle Scholar
  98. 98.
    Kardailsky I, Shukla VK, Ahn JH, Dagenais N, Christensen SK, Nguyen JT, Chory J, Harrison MJ, Weigel D (1999) Science 286:1962CrossRefGoogle Scholar
  99. 99.
    Weigel D, Ahn JI, Blázquez MA, Borevitz JO, Christensen SK, Fankhauser C, Ferrándiz C, Kardailsky I, Malancharuvil EJ, Neff MM, Nguyen JT, Sato S, Wang Z-Y, Xia Y, Dixon RA, Harrison MJ, Lamb CJ, Yanofsky MF, Chory J (2000) Plant Physiol 122:1003CrossRefGoogle Scholar
  100. 100.
    Furini A, Koncz C, Salamini F, Bartels D (1997) EMBO J 16:3599CrossRefGoogle Scholar
  101. 101.
    Kakimoto T (1996) Science 274:982CrossRefGoogle Scholar
  102. 102.
    Sasse F, Buchholz M, Berlin J (1983) Z Naturforsch 38c:910Google Scholar
  103. 103.
    Galbraith DW, Harkins KR, Maddox JM, Ayres NM, Sharma DP, Firoozabady E (1993) Science 220:1049CrossRefGoogle Scholar
  104. 104.
    van der Fits L, Deakin EA, Hoge JHC, Memelink J (2000) Plant Mol Biol 43:495CrossRefGoogle Scholar
  105. 105.
    van der Fits L, Memelink J (2001) Plant J 25:43CrossRefGoogle Scholar
  106. 106.
    St-Pierre B, Vazquez-Flota FA, De Luca V (1999) Plant Cell 11:887CrossRefGoogle Scholar
  107. 107.
    Zhao J, Last RL (1996) Plant Cell 8:2235CrossRefGoogle Scholar
  108. 108.
    Canel C, Lopes Cardoso MI, Whitmer S, van der Fits L, Pasquali G, van der Heijden R, Hoge JHC, Verpoorte R (1998) Planta 205:414CrossRefGoogle Scholar
  109. 109.
    Whitmer S (1999) PhD thesis, Leiden University, The NetherlandsGoogle Scholar
  110. 110.
    Solano R, Stepanova A, Chao Q, Ecker JR (1998) Genes Dev 12:3703CrossRefGoogle Scholar
  111. 111.
    Martin GB, Brommonschenkel S, Chunwongse J, Frary A, Ganal MW, Spivey R, Wu T, Earle ED, Tanksley SD (1993) Science 262:1432CrossRefGoogle Scholar
  112. 112.
    Zhou J, Tang X, Martin GB (1997) EMBO J 16:3207CrossRefGoogle Scholar
  113. 113.
    Liu Q, Kasuga M, Sakuma Y, Abe H, Miura S, Yamaguchi-Shinozaki K, Shinozaki K (1998) Plant Cell 10, 1391CrossRefGoogle Scholar
  114. 114.
    Lloyd AM, Schena M, Walbot V, Davis RW (1994) Science 266:436CrossRefGoogle Scholar
  115. 115.
    Bruce W, Folkerts O, Garnaat C, Crasta O, Roth B, Bowen B (2000) Plant Cell 12:65CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Johan Memelink
    • 1
  • Jan W. Kijne
    • 1
  • Robert van der Heijden
    • 2
  • Rob Verpoorte
    • 2
  1. 1.Institute of Molecular Plant SciencesClusius LaboratoryLeidenThe Netherlands
  2. 2.Division of Pharmacognosy, Leiden/Amsterdam Center for Drug ResearchLeiden UniversityLeidenThe Netherlands

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