Advertisement

Engineering and Characterization of Polymer Surfaces for Biomedical Applications

  • Hans Jörg Mathieu
  • Yann Chevolot
  • Laurence Ruiz-Taylor
  • Didier Léonard
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 162)

Abstract

The application of synthetic polymers in the growing field of materials for medical applications is illustrated by examples from recent work at the Materials Institute of the Swiss Federal Institute of Technology in Lausanne. The review highlights the need for functionalization and chemical control of material surfaces at a molecular/functional level. After a brief introduction into the surface chemical analysis tools, i.e., X-ray Photoelectron Spectroscopy (XPS) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) combined with contact angle measurements, phosphorylcholine biomimicking polymers as well as immobilization of carbohydrates on polystyrene are presented.

Keywords

Polymers Surface analysis Functionalization Immobilization Glycoengineering 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ratner BD, Chilkoti A, Lopez GP (1990) Plasma deposition and treatment for biomaterial applications. In:d’Agostino R (ed) Plasma deposition, treatment and etching of polymers. Academic Press, San Diego, pp 463–516Google Scholar
  2. 2.
    Williams DF ( 1992) Biofunctionality and biocompatibility. In:Williams DF (ed) Medical and dental materials. VCH, Weinheim, pp 1–27Google Scholar
  3. 3.
    Hubbell JA, Langer R (1995) Chem Eng News 73:42–54Google Scholar
  4. 4.
    Mathieu HJ (2001) Surf Interface Anal 32:3–9CrossRefGoogle Scholar
  5. 5.
    Briggs D, Seah MP (1990) (ed) Practical surface analysis, vol I-Auger and X-ray photoelectron spectroscopy, 2nd edn, vol 1. Wiley, ChichesterGoogle Scholar
  6. 6.
    Briggs D, Seah MP (1992) (ed) Practical surface analysis, vol II-ion and neutral spectroscopy, vol 2. Wiley, ChichesterGoogle Scholar
  7. 7.
    Mathieu HJ (2001) Elemental analysis by AES, XPS and SIMS. In:Alfassi ZB (ed) Nondestructive elemental analysis. Blackwell Science, Oxford, pp 201–231Google Scholar
  8. 8.
    ISO (2001) Surface chemical analysis-X-ray photoelectron spectrometers-calibration of energy scales. In:International Standard 15472, 2001Google Scholar
  9. 9.
    Beamson G, Briggs D (1992) High resolution XPS of organic polymers. The Scienta ESCA300 database, Wiley, ChichesterGoogle Scholar
  10. 10.
    Powell CJ, Jablonski A (1999) J Phys Chem Ref Data 28:19–62CrossRefGoogle Scholar
  11. 11.
    Frydman E, Cohen H, Maoz R, Sagiv J (1997) Langmuir 13:5089–5106CrossRefGoogle Scholar
  12. 12.
    Buchwalter LP, Czornyj G (1990) J Vac Sci Tech A 8:781–784CrossRefGoogle Scholar
  13. 13.
    Chaney R, Barth G (1987) Fresenius J Anal Chem 326:143Google Scholar
  14. 14.
    Clark DT, Brennan WJ (1986) J Electron Spectrosc 41:399–410CrossRefGoogle Scholar
  15. 15.
    Storp S (1985) Spectrochim Acta B 40:745–756CrossRefGoogle Scholar
  16. 16.
    Coullerez G, Chevolot Y Léonard D, Xanthopoulos N, Mathieu HJ (1999) J Surf Anal 5:235–239Google Scholar
  17. 17.
    Vickerman JC (ed) (1997) Surface analysis-the principal techniques. Wiley, ChichesterGoogle Scholar
  18. 18.
    Briggs D (1992) Static SIMS-surface analysis of organic materials. In:Briggs D, Seah MP (eds) Practical surface analysis, vol 2-ion and neutral spectroscopy. Wiley, Chichester, pp 367–423Google Scholar
  19. 19.
    Benninghoven A, Stapel D, Brox O, Burkhardt H, Crone C, Thiemann M, Arlinghaus HA (1999) Static SIMS with molecular primary ions. In:SIMS XII. Elsevier, BrusselsGoogle Scholar
  20. 20.
    Stapel D, Thiemann M, Hagenhoff B, Benninghoven A (1999) Secondary ion emission from LB-layers under molecular primary ion bombardment. In:SIMS XII. Elsevier, BrusselsGoogle Scholar
  21. 21.
    Hagenhoff B, Cobben PL, Bendel C, Niehuis E, Benninghoven A (1997) Polymers under SF5 bombardment-a systematic investigation. In:SIMS XI. Wiley, Orlando, FloridaGoogle Scholar
  22. 22.
    Justes DR, Harris RD, Stipdonk MJV, Schweikert AE (1997) A comparison of Cs and C60 primary projectiles for the characterization of GaAs and Si surfaces. In:SIMS XI. Wiley, Orlando, FloridaGoogle Scholar
  23. 23.
    Vickerman JC, Briggs D (eds) (2001) ToF-SIMS: surface analysis by mass spectrometry. IM Publications and Surface Spectra, ChichesterGoogle Scholar
  24. 24.
    Vickerman JC, Swift AW (1997) Secondary ion mass spectrometry. In:Vickerman JC (ed) Surface analysis-the principal techniques. Wiley, Chichester, pp 135–214Google Scholar
  25. 25.
    Young T (1805) Philos Trans R Soc London 96:65Google Scholar
  26. 26.
    Swain PS, Lipowsky R (1998) Langmuir 14:6772–6780CrossRefGoogle Scholar
  27. 27.
    Garbassi F, Morra M, Occhiello E (eds) (1994) Polymer surfaces from physics to technology. Wiley, ChichesterGoogle Scholar
  28. 28.
    Good RJ (1993) Contact angle, wetting, and adhesion: a critical review. In:Mittal KL (ed) Contact angle, wettability and adhesion. VSP-Wiley, Weinheim, pp 3–36Google Scholar
  29. 29.
    Li D (1996) Colloid Surf A 116:1–23CrossRefGoogle Scholar
  30. 30.
    Zisman WA (1964) Relation of equilibrium contact angle to liquid and solid constitution. In:Fowkes FM (ed) Contact angle, wettability, and adhesion. American Chemical Society, Washington, D.C., pp 1–51Google Scholar
  31. 31.
    Boksanyi L, Liardon O, Kovats E (1976) Adv Colloid Interface Sci 6:95–137CrossRefGoogle Scholar
  32. 32.
    Erard J-F, Nagy L, Kovats E (1983) Colloid Surf 9:109–132CrossRefGoogle Scholar
  33. 33.
    Gobet J, Kovats E (1984) Adsorpt Sci Technol 1:111–122Google Scholar
  34. 34.
    Korösi G, Kovats E (1981) J Colloid Surf 2:315–355CrossRefGoogle Scholar
  35. 35.
    Riedo F, Czencz M, Liardon O, Kovats E (1978) Helv Chim Acta 61:1912–1941CrossRefGoogle Scholar
  36. 36.
    de Gennes PG (1985) Rev Mod Phys 57:827–863CrossRefGoogle Scholar
  37. 37.
    Fowkes FM (1964) Contact angle, wettability, and adhesion. Advances in Chemistry Series, vol 43. American Chemical SocietyGoogle Scholar
  38. 38.
    Holloway PJ (1970) Pestic Sci 1:156–163CrossRefGoogle Scholar
  39. 39.
    Öner D, McCarthy TJ (2000) Langmuir 16:7777–7782CrossRefGoogle Scholar
  40. 40.
    Youngblood JP, McCarthy TJ (1999) Macromolecules 32:6800–6806CrossRefGoogle Scholar
  41. 41.
    Walliser A (1992) Caracterisation des interactions liquide-fibres élémentaires par mouillage. Université de Haute Alsace (F), 92-MUHL-0248Google Scholar
  42. 42.
    Connor M (1995) Consolidation mechanisms and interfacial phenomena in thermoplastic powder impregnated composites. EPFL Thesis No 1413Google Scholar
  43. 43.
    Ruiz L (1997) Thesis: synthesis and characterisation of phosphorylcholine containing polymers designed to promote specific cell attachment via surface derivatisation. École Polytechnique Fédérale de Lausanne: LausanneGoogle Scholar
  44. 44.
    Marieb EN (1998) Human anatomy and physiology, 4th edn. Addison-Wesley PublishingGoogle Scholar
  45. 45.
    Williams DF (1987) Definitions in Biomaterials, vol 4. Progress in biomedical engineering. ElsevierGoogle Scholar
  46. 46.
    Kadoma Y, Nakabayashi N, Masuhara E, Yamauchi J (1978) Kobunshi Ronbunshu 35:423–427Google Scholar
  47. 47.
    Chapman D (1993) Langmuir 9:39–45CrossRefGoogle Scholar
  48. 48.
    Hayward JA, Chapman D (1984) Biomaterials 5:135–142CrossRefGoogle Scholar
  49. 49.
    Ishihara K, Aragaki R, Ueda T, Watenabe A, Nakabayashi N (1990) J Biomed Mater Res 24:1069–1077CrossRefGoogle Scholar
  50. 50.
    Ishihara K, Aragaki R,Y amazaki JI, Ueda T, Watenabe A, Nakabayashi N (1990) Seitai Zairyo 8:231–236Google Scholar
  51. 51.
    Ishihara K, Oshida H, Endo Y, Ueda T, Watenabe A, Nakabayashi N (1992) J Biomed Mater Res 26:1543–1552CrossRefGoogle Scholar
  52. 52.
    Lelah MD, Cooper SL (1986) Polyurethanes in medicine. CRC PressGoogle Scholar
  53. 53.
    Ruiz L, Johnston DS, Makohliso SA, Aebischer P, Mathieu HJ (1995) Biomimetic coatings on silicon wafers: synthesis and characterisation in ECASIA 95 Montreux, Switzerland. Mathieu HJ, Reike B, Briggs D (eds.) Wiley, ChichesterGoogle Scholar
  54. 54.
    Yung LL, Cooper LS (1998) Biomaterials 19:31CrossRefGoogle Scholar
  55. 55.
    Baumgartner JN, Yang CZ, Cooper SL (1997) Biomaterials 18:831CrossRefGoogle Scholar
  56. 56.
    Ruiz L, Fine E, Vörös J, Makohliso SA, Léonard D, Johnston DS, Textor M, Mathieu HJ (1999) JBiomater Sci Polym E 10:931–955Google Scholar
  57. 57.
    Peyser P (1989) Glass transition temperatures of polymers. In: Brandrup J, Immergut EH (eds) Polymer handbook. Wiley, pp VI 209–277Google Scholar
  58. 58.
    Ruiz L, Hilborn JG, Léonard D, Mathieu HJ (1998) Biomaterials 19:987–998CrossRefGoogle Scholar
  59. 59.
    Davies MC, Lynn RAP (1990) Crit Rev Biocompat 5:297–341Google Scholar
  60. 60.
    Yianni YP (1992) Biocompatible surfaces based upon biomembrane mimicry In:Quinn PJ, Cherry RJ (eds) Structural and dynamic properties of lipids and membranes. Portland Press, London, UK, pp 187–216Google Scholar
  61. 61.
    Hearn MJ, Briggs D (1988) Surf Interface Anal 11:198–213CrossRefGoogle Scholar
  62. 62.
    Phillips MC, Finer EG, Hauser H (1972) Biochim Biophys Acta 290:397–402CrossRefGoogle Scholar
  63. 63.
    Hauser H (1975) Phospholipid model membranes: demonstration of a structure-activity relationship in chemoreception. Infr Retr Ltd, LondonGoogle Scholar
  64. 64.
    Briggs D, Hearn MJ (1988) Surf Interface Anal 13:647–669Google Scholar
  65. 65.
    Chilkoti A, Castner DG, Ratner BD, Briggs D (1990) J Vac Sci Technol A8:2274Google Scholar
  66. 66.
    Tanuma S, Powell CJ, Penn DR (1993) Surf Interface Anal 21:165–176CrossRefGoogle Scholar
  67. 67.
    Seah MP, Dench WA (1979) Surf Interface Anal 1:2–11CrossRefGoogle Scholar
  68. 68.
    Garbassi F, Morra M, Occhiello E (1994) Surface energetics and contact angle. In:Polymer surfaces from physics to technology. Wiley, Chichester, chap 4, pp 161–219Google Scholar
  69. 69.
    Holly FJ, Refojo MF (1975) J Biomed Mater Res 9:315–326CrossRefGoogle Scholar
  70. 70.
    Lavielle L, Schultz J (1985) J Colloid Interface Sci 106:438–445CrossRefGoogle Scholar
  71. 71.
    Lavielle L, Schultz J,S anfeld A (1985) J Colloid Interface Sci 106:446–451CrossRefGoogle Scholar
  72. 72.
    Andrade JD (1988) Polymer surface dynamics. Plenum Press, New York LondonGoogle Scholar
  73. 73.
    Ratner BD, Weathersby P, Hoffman AS, Kelly MA, Scharpen LH (1978) J Appl Polym Sci 22:643–664CrossRefGoogle Scholar
  74. 74.
    Wirpsza Z (1993) Polyurethanes: chemistry, technology and applications. Polymer science series. Ellis Horwood PTR Prentice HallGoogle Scholar
  75. 75.
    Chevolot Y (1999) Thesis: Surface photoimmobilisation of aryl dyazirine containing carbohydrates-tools toward surface glycoengineering. École Polytechnique Fédérale de Lausanne, LausanneGoogle Scholar
  76. 76.
    Lee YC, Lee RT (1995) Acc Chem Res 28:321–327CrossRefGoogle Scholar
  77. 77.
    Monsigny M (1995) Biofutur 142:27–32CrossRefGoogle Scholar
  78. 78.
    Petrak K (1994) Adv Drug Deliver Rev 13:211–213CrossRefGoogle Scholar
  79. 79.
    Varki A (1995) Glycobiology 3:97–130CrossRefGoogle Scholar
  80. 80.
    Hatanaka K, Takeshige H, Akaike T (1994) Carbohydr Chem 13:603–610CrossRefGoogle Scholar
  81. 81.
    Hermanson GT, Mallia AK, Smith PK (1992) Immobilized affinity ligand techniques. Academic PressGoogle Scholar
  82. 82.
    Kobayashi K, Kobayashi A, Akaike T (1994) Method Enzymol 247:409–419CrossRefGoogle Scholar
  83. 83.
    Onyiriuka EC (1990) Appl Spectrosc 44:808–811CrossRefGoogle Scholar
  84. 84.
    Kobyashi K, Akaike T, Usui T (1994) Method Enzymol 242:226–235CrossRefGoogle Scholar
  85. 85.
    Guire PE (1990) Method of improving the biocompatibility of solid surfaces. Pat 4-973-493, Bio-Metric Systems, Inc, USGoogle Scholar
  86. 86.
    Guire PE (1990) Biocompatible Coating for Solid Surfaces. Pat 4-979-959, Bio-Metric Systems, Inc, USGoogle Scholar
  87. 87.
    Erdtmann M, Keller R, Baumann H (1994) Biomaterials 15:1043–1049CrossRefGoogle Scholar
  88. 88.
    Anderson AB, Tran TH, Hamilton MJ, Chudzik SJ, Hasting BP, Melchior MJ, Hergen-rother RW (1996) Am J Neuroradiol 17:859–863Google Scholar
  89. 89.
    Anderson AB, Enrico LS, Melchior MJ, Pietig JA, Tran LV, Tran TH, Duquette PH (1994) Photochemical immobilization of heparin to reduce thrombogenesis. Tewntieth Annual Meeting of the Society for Biomaterials, Boston, MA, USAGoogle Scholar
  90. 90.
    Sigrist H, Collioud A, Clémence J-F, Gao H, Luginbühl R, Sänger M, Sundarababu G (1995) Opt Eng 34:2339–2347CrossRefGoogle Scholar
  91. 91.
    Gao H, Sanger M, Luginbühl R, Sigrist H (1995) Biosens Biolectron 10:317–328CrossRefGoogle Scholar
  92. 92.
    Gao H, Luginbühl R, Sigrist H (1997) Sens Actuators B 38/39:38–41CrossRefGoogle Scholar
  93. 93.
    Collioud A, Clémence J-F, Sänger M, Sigrist H (1993) Bioconjugate Chem 4:528–536CrossRefGoogle Scholar
  94. 94.
    Léonard D, Chevolot Y, Bucher O, Haenni W, Sigrist H, Mathieu HJ (1998) Surf Interface Anal 26:783–792CrossRefGoogle Scholar
  95. 95.
    Chevolot Y, Bucher O, Léonard D, Mathieu HJ, Sigrist H (1999) Bioconjugate Chem 10:169–175CrossRefGoogle Scholar
  96. 96.
    Léonard D, Chevolot Y, Bucher O, Sigrist H, Mathieu HJ (1998) Surf Interface Anal 26:793–799CrossRefGoogle Scholar
  97. 97.
    Léonard D, Chevolot Y, Heger F, Martins J, Crout DHG, Sigrist H, Mathieu HJ (2001) Surf Interface Anal 2001:457–464CrossRefGoogle Scholar
  98. 98.
    Yamashita K (1989) Method Enzymol 179:331CrossRefGoogle Scholar
  99. 99.
    Stockert RJ, Morell AG, Ashwell G (1991) 12:441Google Scholar
  100. 100.
    Baenziger JU, Maynard Y (1980)J Biol Chem 255:4607–4613Google Scholar
  101. 101.
    Schwartz AL (1990) Annu Rev Immunol 8:195–229CrossRefGoogle Scholar
  102. 102.
    Ashwell G, Harford J (1982) Annu Rev Biochem 51:531–554CrossRefGoogle Scholar
  103. 103.
    Kawasaki T, Ashwell G (1976)J Biol Chem 251:12Google Scholar
  104. 104.
    Malissard M, Zeng S, Berger EG (1999) Bioconjugate Chem 16:125Google Scholar
  105. 105.
    Chevolot Y, Martins J, Milosevic N, Léonard D, Zeng S, Malissard M, Berger EG, Maier P, Mathieu HJ, Crout DHG, Sigrist H (2001) Bioorgan Med Chem 9:2943–2953CrossRefGoogle Scholar
  106. 106.
    Sigrist H, Chevolot Y, Crout D, Martins J, Mathieu HJ, Lohmann D (2000) European Patent Application 99112422.3-2110Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Hans Jörg Mathieu
    • 1
  • Yann Chevolot
    • 2
  • Laurence Ruiz-Taylor
    • 3
  • Didier Léonard
    • 4
  1. 1.Materials InstituteÉcole Polytechnique Fédérale de Lausanne (EPFL)Lausanne EPFLSwitzerland
  2. 2.Laboratoires Goëmar, UMR 1931 CNRS/Laboratoires GoëmarRoscoffFrance
  3. 3.Zyomyx Inc.HaywardUSA
  4. 4.Analytical Technology, Microanalysis groupGE Plastics EuropeBergen op ZoomThe Netherlands

Personalised recommendations